Results 31 to 40 of about 216,260 (210)

Risk factors for vancomycin resistance in patients with Enterococcus faecium bloodstream infections: an analysis of the Munich Multicentric Enterococci Cohort

Microbiology Spectrum
Enterococcus faecium is difficult to treat owing to its intrinsic and acquired resistance to antibiotics, particularly vancomycin. Vancomycin-resistant Enterococcus faecium is an important cause of bloodstream infections in healthcare settings with ...
Laura Wagner, Milena Wurst, Johanna Erber, Tobias Bachfischer, Bernhard Haller, Sabine Gleich, Karl Dichtl, Roland M. Schmid, Julian Triebelhorn, Florian Voit, Ulrich Seybold, Dirk H. Busch, Patrick C. Rämer, Christoph D. Spinner, Jochen Schneider, Kathrin Rothe   +15 more
doaj   +1 more source

A Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-resistant E. coli and Targets Cell-Wall Synthesis.

ACS Chemical Biology, 2019
The emergence of multidrug-resistant Gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae, is a major health problem that necessitates the development of new antibiotics.
Alexandra Antonoplis, Xiaoyu Zang, Tristan Wegner, P. Wender, L. Cegelski   +4 more
semanticscholar   +1 more source

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

Frontiers in Microbiology, 2018
Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by binding to the D-Ala-D-Ala termini of lipid II. For long, it has been used as a last resort antibiotic.
Nigam M. Mishra, Izabela Stolarzewicz, Izabela Stolarzewicz, David Cannaerts, Joris Schuermans, Rob Lavigne, Yannick Looz, Bart Landuyt, Liliane Schoofs, Dominique Schols, Jan Paeshuyse, Peter Hickenbotham, Martha Clokie, Walter Luyten, Walter Luyten, Erik V. Van der Eycken, Erik V. Van der Eycken, Yves Briers, Yves Briers   +18 more
doaj   +1 more source

Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration

Dose-Response
Objective: To evaluate the influencing factors of Vancomycin trough concentration in blood, construct an individualized Vancomycin administration model for rational use of Vancomycin. Methods: The clinical data of Vancomycin trough concentration in blood
Lin Wang, Yuhuang Wang, Chunyan Yang, Jia Jiang, Huifang Wang, Mingcai Wu   +5 more
doaj   +1 more source

An Unusual Case of Ototoxicity with Use of Oral Vancomycin

Case Reports in Infectious Diseases, 2018
Introduction. Systemic absorption of oral vancomycin is poor due to the size of the molecule and its pharmacokinetics. It has an elimination half life of 5–11 hours in patients with normal renal function.
Umut Gomceli, Srija Vangala, Cosmina Zeana, Paul J. Kelly, Manisha Singh   +4 more
doaj   +1 more source

Vancomycin-resistant Staphylococcus aureus (VRSA) can overcome the cost of antibiotic resistance and may threaten vancomycin's clinical durability.

PLoS Pathogens
Vancomycin has proven remarkably durable to resistance evolution by Staphylococcus aureus despite widespread treatment with vancomycin in the clinic. Only 16 cases of vancomycin-resistant S. aureus (VRSA) have been documented in the United States.
Samuel E Blechman, Erik S Wright
doaj   +1 more source

Appropriate vancomycin use in a Malaysian tertiary hospital based on current HICPAC recommendations

Journal of Infection in Developing Countries, 2014
Introduction: Antibiotic resistance is a rapidly emerging problem. A major concern is methicillin-resistant Staphylococcus aureus (MRSA), especially in developing countries where cost-effectiveness is imperative.
Farida Islahudin, Hui-Yeah Ong
doaj   +1 more source

Necessity of vancomycin trough concentrations to manage uncomplicated acute bacterial skin and skin structure infections: a laboratory stewardship analysis

Drugs in Context, 2023
Background: Recent recommendations by the American Society of Health System Pharmacists and Infectious Disease Society of America have provided guidance regarding vancomycin dosing and monitoring in serious infections (including methicillin-resistant ...
Andrew Merker, Kartik Anne, Justin Rayyan, Milena Murray   +3 more
doaj   +1 more source

Short- and long-term effects of oral vancomycin on the human intestinal microbiota

Journal of Antimicrobial Chemotherapy, 2016
Background Oral vancomycin remains the mainstay of therapy for severe infections produced by Clostridium difficile, the most prevalent cause of healthcare-associated infectious diarrhoea in developed countries.
Sandrine Isaac, J. Scher, Ana Djukovic, N. Jiménez, D. Littman, S. Abramson, E. Pamer, C. Ubeda   +7 more
semanticscholar   +1 more source

Predicted Vancomycin Dosage Requirement in Patients With Hematological Malignancies and Dosage Dynamic Adjustment

Frontiers in Pharmacology, 2022
Purpose: The purpose of this study was 1) to predict the requisite vancomycin daily dose (Dvan) used in the target patients suffering from both bacterial infection and hematological malignancies and 2) to construct a vancomycin-dose-graphical tool to ...
Xiangqing Song, Yi Wu
doaj   +1 more source