Results 31 to 40 of about 227,152 (290)

Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]

, 2017
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De, Mascellino, Maria Teresa, Oliva, Alessandra   +2 more
core   +1 more source

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

Frontiers in Microbiology, 2018
Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by binding to the D-Ala-D-Ala termini of lipid II. For long, it has been used as a last resort antibiotic.
Nigam M. Mishra, Izabela Stolarzewicz, Izabela Stolarzewicz, David Cannaerts, Joris Schuermans, Rob Lavigne, Yannick Looz, Bart Landuyt, Liliane Schoofs, Dominique Schols, Jan Paeshuyse, Peter Hickenbotham, Martha Clokie, Walter Luyten, Walter Luyten, Erik V. Van der Eycken, Erik V. Van der Eycken, Yves Briers, Yves Briers   +18 more
doaj   +1 more source

Vancomycin

Medical Clinics of North America, 1995
Vancomycin is a nontoxic glycopeptide antibiotic most often used to treat serious gram-positive infections, C. difficile diarrhea/colitis, and endocarditis and hemodialysis shunt prophylaxis. Vancomycin should not be added to drug regimens for gram-positive coverage, and the empiric use of vancomycin should be discouraged to avoid the emergence of VRE.
openaire   +2 more sources

Faecal microbiota transplantation : a regulatory hurdle? [PDF]

, 2017
During faecal microbiota transplantation, stool from a healthy donor is transplanted to treat a variety of dysbiosis-associated gut diseases. Competent authorities are faced with the challenge to provide adequate regulation.
De Spiegeleer, Bart, Janssens, Yorick, Verbeke, Frederick, Wynendaele, Evelien   +3 more
core   +2 more sources

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

An Unusual Case of Ototoxicity with Use of Oral Vancomycin

Case Reports in Infectious Diseases, 2018
Introduction. Systemic absorption of oral vancomycin is poor due to the size of the molecule and its pharmacokinetics. It has an elimination half life of 5–11 hours in patients with normal renal function.
Umut Gomceli, Srija Vangala, Cosmina Zeana, Paul J. Kelly, Manisha Singh   +4 more
doaj   +1 more source

The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]

, 2018
Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D, Ferrell, Andrea, Hsiung, Andre, Humphries, Romney M, Kircher, Susan, Krause, Kevin M, Malherbe, Rianna   +6 more
core   +2 more sources

Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms. [PDF]

, 2020
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S.
Allan, RN, Angus, EM, Coates, ARM, Frapwell, CJ, Howlin, RP, Hu, Y, Skipp, PJ, Webb, JS   +7 more
core   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration

Dose-Response
Objective: To evaluate the influencing factors of Vancomycin trough concentration in blood, construct an individualized Vancomycin administration model for rational use of Vancomycin. Methods: The clinical data of Vancomycin trough concentration in blood
Lin Wang, Yuhuang Wang, Chunyan Yang, Jia Jiang, Huifang Wang, Mingcai Wu   +5 more
doaj   +1 more source