Toxin-antitoxin (TA) systems are composed of two components. The toxin is typically a stable protein, which exhibits cytostatic or cytotoxic activity in the cells that express it. The antitoxin is either an unstable protein or RNA, which inhibits the activity of the toxin and therefore enables normal cell growth.
openaire +1 more source
VapCs of Mycobacterium tuberculosis Cleave RNAs Essential for Translation:VapCs of M. tuberculosis cleave tRNAs and 23S rRNA [PDF]
The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin (TA) modules contribute to this persistence.
Gerdes, Kenn +3 more
core
The interplay between plasmids in Shigella sonnei [PDF]
Shigella sonnei causes bacillary dysentery in higher-income countries, with emerging antimicrobial resistance spread by plasmids. My thesis aimed to investigate the interplay between S.
Lee, Qian
core +2 more sources
A Tale about Shigella: Evolution, Plasmid, and Virulence. [PDF]
Haidar-Ahmad N +4 more
europepmc +1 more source
Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems. [PDF]
Martyn JE +6 more
europepmc +1 more source
Virulence plasmid pINV as a genetic signature for <i>Shigella flexneri</i> phylogeny. [PDF]
Pilla G, Arcari G, Tang CM, Carattoli A.
europepmc +1 more source
Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor. [PDF]
Sun H +9 more
europepmc +1 more source
Genome Mining Shows Ubiquitous Presence and Extensive Diversity of Toxin-Antitoxin Systems in Pseudomonas syringae. [PDF]
Kandel PP +5 more
europepmc +1 more source
Comparative in silico analysis of vapBC3 toxin-antitoxin system in Mycobacterium Bovis and Mycobacterium tuberculosis. [PDF]
Shafipour M +4 more
europepmc +1 more source
The transcription of two Rh-B8 vapBC modules was activated during the early infection.
Yan Liu (25061) +10 more
openalex +1 more source

