Results 171 to 179 of about 2,020 (179)

Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin–Antitoxin System, Including the Development of an Inhibitor That Activates VapC

Journal of Medicinal Chemistry, 2020
Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K. pneumoniae remains lacking; therefore, it is necessary to explore this information for the development of antibacterial ...
Sung-Min Kang, Chenglong Jin, Do-Hee Kim, Yuno Lee, Bong-Jin Lee   +4 more
openaire   +2 more sources

Are all VapC toxins of Mycobacterium tuberculosis endowed with enigmatic RNase activity?

Journal of Biosciences
Mycobacterium tuberculosis (M. tb) employs an extensive network of more than 90 toxin-antitoxin systems, and among them, VapC toxins are the most abundant. While most VapCs function as classical RNases with toxic effects, a significant number of them do not exhibit toxicity.
Sheeba Zarin, Anwar Alam, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham   +3 more
openaire   +2 more sources

VaPCE: Validation tool for postcoordinated SNOMED CT expressions (Preprint)

BACKGROUND The digitalization of healthcare has increased the demand for efficient data exchange, emphasizing semantic interoperability. SNOMED CT, a comprehensive terminology with over 360,000 medical concepts, supports this need. But it cannot cover all medical scenarios, particularly in complex cases.
Tessa Ohlsen, Viola Hofer, Josef Ingenerf   +2 more
openaire   +1 more source

Ингибирование токсина VapC – способ предотвращения образования покоящихся форм микобактерий

Прикладная биохимия и микробиология, 2016
openaire   +1 more source

Faculty Opinions recommendation of Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2011
Ambrose Cheung, Niles Donegan
openaire   +1 more source

A modification of the VAPC PTB brace.

Artificial limbs, 1971
openaire   +1 more source

Structure of the Shigella flexneri VapC mutant D7A

, 2015
Kang Xu, Emil Dedic, Ditlev E. Brodersen
openalex   +1 more source

VAPC環境制御装置 (病院型) の評価

, 1979
青山 孝, 鈴木 祥生, 中島 昭夫
openalex   +1 more source

VAPC-1 Targeted 64Cu-TP3805 kit preparation and evaluation for translational research in humans

, 2016
Sushil Tripathi, Edouard J. Trabulsi, Peter A. McCue, Pardeep Kumar, Leonard G. Gomella, Mathew L. Thakur   +5 more
openalex