Results 41 to 50 of about 16,660 (115)

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal, Georcki Ropón‐Palacios, Claudina Sancho, Jhon Pérez‐Silva, Kewin Otazu, Gustavo E. Olivos‐Ramirez, Karolyn Vega‐Chozo, Yaritza L. Ramirez‐Díaz, Manuel E. Chenet‐Zuta, Ivonne Navarro del Aguila, Mario De la Cruz Flores, Cinthia Aguiar, Ihosvany Camps   +12 more
wiley   +1 more source

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics

MedComm, Volume 7, Issue 1, January 2026.
This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yunzheng Yan, Yaqin Sun, Guangyan Sun, Cheng Niu, Xinyuan Zhao, Ming Zhao, Tongyao Liu, Suyue Zhang, Hui Zhai, Ankang Liu, Shouzhi Yu, Shuyuan Pan, Wu Zhong, Yuntao Zhang, Song Li   +14 more
wiley   +1 more source

Ricin as a Biothreat Agent: From Molecular Mechanisms to Clinical Toxicology, Forensic Aspects, and Risk Mitigation

BioMed Research International, Volume 2026, Issue 1, 2026.
Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote.
Miroslav Pohanka, Poorani Gurumallesh Prabu   +1 more
wiley   +1 more source

A produção de vacinas é estratégica para o Brasil

História, Ciências, Saúde: Manguinhos, 2003
A produção de imunobiológicos deveria ser assumida pelo governo federal como atividade estratégica para o país e tratada em plano diretor que instituísse mecanismos para assegurar competitividade aos laboratórios nacionais.
Risi Júnior João Baptista
doaj  

Biological invasions: a global assessment of geographic distributions, long‐term trends, and data gaps

Biological Reviews, Volume 100, Issue 6, Page 2542-2583, December 2025.
ABSTRACT Biological invasions are one of the major drivers of biodiversity decline and have been shown to have far‐reaching consequences for society and the economy. Preventing the introduction and spread of alien species represents the most effective solution to reducing their impacts on nature and human well‐being.
Hanno Seebens, Laura A. Meyerson, David M. Richardson, Bernd Lenzner, Elena Tricarico, Franck Courchamp, Alla Aleksanyan, Emre Keskin, Hanieh Saeedi, Perpetra Akite, Jake M. Alexander, Sarah A. Bailey, Dino Biancolini, Tim M. Blackburn, Hans Juergen Boehmer, Alejandro Bortolus, Marc W. Cadotte, César Capinha, James T. Carlton, Jo Anne Crouch, Curtis C. Daehler, Franz Essl, Llewellyn C. Foxcroft, Jason D. Fridley, Nicol Fuentes, Mirijam Gaertner, Bella Galil, Emili García‐Berthou, Pablo García‐Díaz, Sylvia Haider, Liam Heneghan, Kevin A. Hughes, Cang Hui, Ekin Kaplan, Andrew M. Liebhold, Chunlong Liu, Elizabete Marchante, Hélia Marchante, Alicia Marticorena, David W. Minter, Rodrigo A. Moreno, Wolfgang Nentwig, Aidin Niamir, Ana Novoa, Ana L. Nunes, Aníbal Pauchard, Sebataolo Rahlao, Anthony Ricciardi, James C. Russell, K.V. Sankaran, Anna Schertler, Evangelina Schwindt, Ross T. Shackleton, Daniel Simberloff, David L. Strayer, Alifereti Tawake, Marco Thines, Cristóbal Villaseñor‐Parada, Jean Ricardo Simões Vitule, Viktoria Wagner, Victoria Werenkraut, Karsten Wesche, Demian A. Willette, Rafael D. Zenni, Petr Pyšek   +64 more
wiley   +1 more source

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.

PLoS Pathogens
Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus.
Todd M Bell, Paul Facemire, Jeremy J Bearss, Jo Lynne Raymond, Jennifer Chapman, Xiankun Zeng, Joshua D Shamblin, Janice A Williams, Douglas W Grosenbach, Dennis E Hruby, Inger K Damon, Arthur J Goff, Eric M Mucker   +12 more
doaj   +1 more source

Characterization of a nondestructive beam profile monitor using luminescent emission

Physical Review Special Topics. Accelerators and Beams, 2007
The LHC (large hadron collider) [LHC study group: LHC. The large hadron collider conceptual design; CERN/AC/95-05] is the future p-p collider under construction at CERN, Geneva.
A. Variola, R. Jung, G. Ferioli
doaj   +1 more source

Childhood and Adolescent Environmental Risk Factors for Multiple Sclerosis: A Systematic Review With Meta‐Analysis

European Journal of Neurology, Volume 32, Issue 11, November 2025.
The review analyzed 87 studies from 20 countries on environmental risk factors for MS. EBV infection increased MS risk, while breastfeeding showed limited protection. Adverse social experiences, active smoking, and obesity in childhood/adolescence raised risk, whereas normal BMI was protective.
Bruno Kusznir Vitturi, Maria Cellerino, Daniele Boccia, Emmanuelle Leray, Jorge Correale, Ruth Dobson, Ingrid van der Mei, Kazuo Fujihara, Matilde Inglese   +8 more
wiley   +1 more source

EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses

Journal of Immunology Research, 2015
Concerns that variola viruses might be used as bioweapons have renewed the interest in developing new and safer smallpox vaccines. Variola virus genomes are now widely available, allowing computational characterization of the entire T-cell epitome and ...
Magdalena Molero-Abraham, John-Paul Glutting, Darren R. Flower, Esther M. Lafuente, Pedro A. Reche   +4 more
doaj   +1 more source

Designing a smallpox B-cell and T-cell multi-epitope subunit vaccine using a comprehensive immunoinformatics approach

Microbiology Spectrum
Smallpox is a highly contagious human disease caused by the variola virus. Although the disease was eliminated in 1979 due to its highly contagious nature and historical pathogenicity, with a mortality rate of up to 30%, this virus is an important ...
Changqing Yu, Qi Wu, Jiuqing Xin, Qiujuan Yu, Zhixin Ma, Mengzhou Xue, Qingyuan Xu, Chunfu Zheng   +7 more
doaj   +1 more source