Results 91 to 100 of about 8,222 (211)

Effects of three-times-per-week versus on-demand tadalafil treatment on erectile function and continence recovery following bilateral nerve sparing radical prostatectomy: Results of a prospective, randomized, and single-center study [PDF]

, 2015
Erectile dysfunction (ED) and urinary incontinence after bilateral nerve-sparing radical prostatectomy (BNSRP) still remain major causes of morbidity. Phosphodiesterase type 5 inhibitors (PDE5-Is) have a role in the treatment of ED after BNSRP.
Heidenreich, Sanda, Eardley, Fibbi, Morelli, Gacci, Rosen, Van der Walt, McVary, Seckiner, Reis, Beck, Burnett, Salonia, Giuliano, Schwartz, Mulhall, Pavlovich, Montorsi, Mirone, Morelli, Andersson, John, Kundu, Touijer, Stanford, Goode, Ribeiro, Wille, Avery, Çetinel, Wang   +31 more
core   +2 more sources

Erectile dysfunction in cardiovascular patients: A prospective study of the eNOS gene T‐786C, G894T, and INTRON variable number of the tandem repeat functional interaction

Andrology, Volume 13, Issue 4, Page 794-803, May 2025.
Abstract Background Cardiovascular disease induces erectile dysfunction modulated by endothelial nitric oxide synthase enzyme and an impaired ejection fraction that restricts penis vascular congestion. However, the mechanisms regulating endothelial dysfunction are not understood.
Ana Segura, Javier Muriel, Pau Miró, Laura Agulló, Vicente Arrarte, Patricia Carracedo, Thomas Zandonai, Ana M Peiró   +7 more
wiley   +1 more source

CORRECTION CHRONIC ISCHEMIA FINITE COMBINATION OF VARDENAFIL AND PENTOXIFYLLINE EXPERIMENT

Кубанский научный медицинский вестник, 2016
Experimental work conducted on Wistar rat line. Ischemia was simulated on the shin muscles of rats. Muscle ischaemia correction performed intragastric administration of pentoxifylline at a dose of 60 mg / kg of vardenafil dose of 0.9 mg / kg daily for 28
K. I. Lavrinenko, A. S. Belous, G. S. Mal, E. B. Artyushkova, E. A. Loyko   +4 more
doaj  

Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation‐induced deficits in spatial pattern separation

Synapse, 2020
Sleep deprivation (SD) is known to impair hippocampus‐dependent memory processes, in part by stimulating the phosphodiesterase (PDE) activity. In the present study, we assessed in mice whether SD also affects spatial pattern separation, a cognitive ...
Pim R. A. Heckman, Femke Roig Kuhn, F. Raven, Youri G Bolsius, J. Prickaerts, P. Meerlo, R. Havekes   +6 more
semanticscholar   +1 more source

Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease

BJU International, Volume 135, Issue 5, Page 810-817, May 2025.
Objectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Sophie L. Harding, Marcus M. Ilg, Stephen A. Bustin, David J. Ralph, Selim Cellek   +4 more
wiley   +1 more source

Gamma radiation-induced impairment of hippocampal neurogenesis, comparison of single and fractionated dose regimens Deterioro de la neurogénesis en el hipocampo inducida por radiación gamma, comparación de los regímenes de dosis única y fraccionada [PDF]

, 2012
Radiation therapy of the brain is associated with many consequences, including cognitive disorders. Pathogenesis of radiation induced cognitive disorder is not clear, but reduction of neurogenesis in hippocampus may be an underlying reason. 24 adult male
Azami, N.S., Jahanshahi, M., Khoshbin khoshnazar, A.R.   +2 more
core  

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Volume 6, Issue 3, March 2025.
The figure highlights the interplay of genetic and epigenetic mechanisms in pulmonary hypertension (PH) and their implications for therapeutic strategies. The genetic mechanism section features key genes implicated in PH pathogenesis. The epigenetic mechanism encompasses DNA methylation, RNA methylation, noncoding RNAs (miRNA, lncRNA), and histone ...
Joseph Adu‐Amankwaah, Qiang You, Xiaoer Liu, Jiayi Jiang, Dongqi Yang, Kuntao Liu, Jinxiang Yuan, Yanfang Wang, Qinghua Hu, Rubin Tan   +9 more
wiley   +1 more source

Vericiguat Global Study in Participants with Chronic Heart Failure: Design of the VICTOR trial

European Journal of Heart Failure, Volume 27, Issue 2, Page 209-218, February 2025.
Design of the vericiguat global study in participants with chronic heart failure (VICTOR) trial. GDMT, guideline‐directed medical therapy; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; HHF, hospitalization for heart failure; IV, intravenous; LVEF, left ventricular ejection fraction; NT‐proBNP, N‐terminal pro‐B‐type natriuretic
Yogesh N.V. Reddy, Javed Butler, Kevin J. Anstrom, Robert O. Blaustein, Marc P. Bonaca, Stefano Corda, Justin A. Ezekowitz, Carolyn S.P. Lam, Eldrin F. Lewis, JoAnn Lindenfeld, Ciaran J. McMullan, Robert J. Mentz, Christopher O'Connor, Mahesh Patel, Piotr Ponikowski, Giuseppe M.C. Rosano, Clara I. Saldarriaga, Michele Senni, James Udelson, Adriaan A. Voors, Faiez Zannad   +20 more
wiley   +1 more source

Experimental substantiation of an opportunity of the use of vardenafil for pharmacological preconditioning in surgery

Кубанский научный медицинский вестник, 2015
The possibility of vardenafil using for pharmacological preconditioning in surgery is studied. Experiment was carried out on Wistar rats. The influence of vardenafil on the survival of pedicled isolated skin flap and the state of the microvasculature in ...
I. M. Kolesnik, M. V. Pokrovskiy, V. A. Lasarenko   +2 more
doaj  

Phosphodiesterase-5 inhibitors for erectile dysfunction in patients with diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Indian Journal of Endocrinology and Metabolism, 2015
Background and Aims: Patients with diabetes mellitus frequently experience erectile dysfunction. This systematic review and meta-analysis were conducted to find efficacy and tolerability of phosphodiesterase 5 (PDE5) inhibitors in patients with diabetes ...
Yatan Pal Singh Balhara, Siddharth Sarkar, Rishab Gupta   +2 more
doaj   +1 more source