Results 131 to 140 of about 949 (170)

A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood‒brain barrier selective-opening. [PDF]

Acta Pharm Sin B
Zhang Z, Cao W, Xing H, Guo S, Huang L, Wang L, Sui X, Lu K, Luo Y, Wang Y, Yang J.   +10 more
europepmc   +1 more source

Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart disease

Gaziano L, Allara E, Giambartolomei C, Stacey D, Zhao JH, Dashti H, Jiang T, Ritchie SC, Ferolito BR, Rasooly D, Peloso GM, Di Angelantonio E, Wheeler E, Pietzner M, Assimes TL, Wilson PW, Cho K, Aragam KG, Burgess S, Danesh J, Langenberg C, Casas JP, Michael Gaziano J, Pereira AC, Butterworth AS.   +24 more
europepmc   +1 more source

Varespladib (LY315920) inhibits neuromuscular blockade induced by Oxyuranus scutellatus venom in a nerve-muscle preparation

Toxicon, 2020
The phospholipase A2 (PLA2) inhibitors varespladib (LY315920) and its orally available derivative methyl-varespladib (LY333013) have been proposed as potential therapies for the treatment of snakebite envenomings in which toxicity depends on the action of PLA2s.
José María Gutiérrez, Matthew R Lewin, Yoko Oshima-franco   +2 more
exaly   +6 more sources

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Varespladib (LY315920) prevents neuromuscular blockage and myotoxicity induced by crotoxin on mouse neuromuscular preparations

Toxicon, 2021
Varespladib (LY315920) is a synthetic phospholipase A2 (PLA2) inhibitor that has been demonstrating antiophidic potential against snake venoms that present PLA2 neurotoxins. In this study, we evaluate the capacity of Varespladib to inhibit the neuromuscular effects of crotoxin (CTX), the main toxic component of Crotalus durissus terrificus snake venom,
Mylle Karoline Ramos Pinto, Consuelo Latorre Fortes-dias, Walter Luís Garrido Cavalcante   +2 more
exaly   +5 more sources

Varespladib (LY315920) neutralises phospholipase A2 mediated prothrombinase-inhibition induced by Bitis snake venoms

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 2020
Anticoagulant toxicity is a common function of venoms produced by species within the Bitis genus. Potent inhibition of the prothrombinase complex is an identified mechanism of action for the dwarf species B. cornuta and B. xeropaga, along with some localities of B. atropos and B. caudalis.
Nicholas J Youngman, Andrew A Walker, Bryan G Fry   +2 more
exaly   +6 more sources

Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats.

Toxicon, 2022
In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor - VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats.
Rosimeire Silva-Carvalho, Matheus Z. Gaspar, Luiz H.B. Quadros, Luís G.G. Lobo, R. Giuffrida, C. L. Santarém, E. O. Silva, J. Gerez, Nelson J. Silva, S. Hyslop, B. Lomonte, R. S. Floriano   +11 more
semanticscholar   +5 more sources

Anti-Inflammatory Effects of Varespladib Methyl in Diabetic Patients with Acute Coronary Syndrome

Cardiovascular Drugs and Therapy, 2011
Secretory phospholipase A(2) group IIA (sPLA(2-)IIA) concentration and activity are associated with increased risk of cardiovascular events in acute coronary syndrome (ACS) patients. This study evaluated baseline differences in sPLA(2)-IIA concentration and other inflammatory markers in ACS patients with and without diabetes, and the inflammatory ...
Robert S Rosenson
exaly   +5 more sources

Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA2.

Toxicon
Snakebite envenomation often leads to severe visceral injuries, including acute liver injury (ALI). However, the toxicity mechanism remains unclear. Moreover, varespladib can directly inhibit phospholipase A2 (PLA2) in snake venom, but its protective effect on snakebite-induced ALI and the mechanism have not been clarified.
Wenjie Zhao, Jiahao Liu, Sidan Wang, Qinqin Tao, Qiongqiong Lei, Chunhong Huang   +5 more
semanticscholar   +4 more sources

Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms.

Toxicon, 2020
J. Gutiérrez, M. Lewin, David J. Williams, B. Lomonte   +3 more
semanticscholar   +4 more sources