Results 141 to 150 of about 3,116,070 (323)

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Neotectonics assessment using geomorphic indices: A study from the passive continental margin of India

open access: yesGeology, Ecology, and Landscapes
The response of landforms to tectonic deformative processes can be effectively understood by using geomorphic indices. The objective of this study is to evaluate the extent of neotectonic activities in the fourth-order sub-basins of a tropical river ...
C D Aju   +3 more
doaj   +1 more source

Heart rate variability. Standards of measurement, physiological interpretation, and clinical use

open access: yes, 1996
Marek Malik   +6 more
semanticscholar   +1 more source

Polyharmonicity, Almansi-type decompositions and Fueter-Sce theorem for several Clifford variables [PDF]

open access: yesarXiv
We study some harmonic properties of slice regular functions in one and several Clifford variables and give explicit formulas of the iterated Laplacian applied to slice regular functions and to their spherical derivative, which are new also in the one variable context.
arxiv  

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

open access: yesMolecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien   +7 more
wiley   +1 more source

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