Results 181 to 190 of about 45,923 (289)

QMODE+ ablation mode: optimal parameter setting and impedance-adapted strategies. [PDF]

Front Cardiovasc Med
Shi X, Sun M, Wang Z, Liang M, Jin Z, Ding J.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Assessment of Biophysical Parameters and Acute Lesion Effectiveness in Atrial Fibrillation Ablation Using a Very High-Power Short-Duration Strategy. [PDF]

Cureus
Tahir S, Rogers J, Shetty V, Akula D.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Accuracy of electrical impedance tomography to detect perfusion defects in pulmonary embolism. [PDF]

Crit Care
Rodrigues EAP, Pacheco EC, Nakamura MAM, Dos Santos ACC, de Melo JL, Plens GM, Alcala GC, Victor M, Xin Y, Cereda M, Gomes S, Lee HJ, Ribeiro BM, Ianotti RM, Freitas-Filho O, Alves-Jr JL, Berra L, Morais CCA, Bertacchini L, Mlček M, Souza R, Borges JB, Costa ELV, Amato MBP.   +23 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Estimating stiffness and damping of a novel variable impedance actuator based on adjusting viscoelastic properties of thermoresponsive polycaprolactone in harmonic motions. [PDF]

Sci Rep
Exley T, Johnson D, Jafari A.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Self-Oscillatory Neuron-like Devices for Unconventional Computing Applications. [PDF]

Chem Rev
Rivera-Sierra G, Bisquert J, Fenollosa R.   +2 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source