Results 61 to 70 of about 44,318 (258)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Modified Dynamic Movement Primitive-Based Closed Ankle Reduction Technique Learning and Variable Impedance Control for a Redundant Parallel Bone-Setting Robot

Machines
Traditional fracture reduction relies heavily on the surgeon’s experience, which hinders the transmission of skills. This specialization bottleneck, coupled with the high demands on physical strength, significantly limits the efficiency of daily ...
Zhao Tan, Yahui Zhang, Jiahui Yuan, Xu Song, Jialong Zhang, Guilin Wen, Xiaoyan Hu, Hanfeng Yin   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Bio-Signal-Guided Robot Adaptive Stiffness Learning via Human-Teleoperated Demonstrations

Biomimetics
Robot learning from human demonstration pioneers an effective mapping paradigm for endowing robots with human-like operational capabilities. This paper proposes a bio-signal-guided robot adaptive stiffness learning framework grounded in the conclusion ...
Wei Xia, Zhiwei Liao, Zongxin Lu, Ligang Yao   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Fast impedance matching for the ion cyctron resonance heating system based on capacitors at the EAST tokamak [PDF]

EPJ Web of Conferences
This paper presents an impedance matching system based on real-time feedback control, designed to address impedance mismatching issues in radio frequency (RF) systems.
Guo Yaoyao, Liu Lunan, Zhang Xinjun, Qin Chengming, Zhang Wei, Chen Qingqing   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Improving Sit/Stand Loading Symmetry and Timing Through Unified Variable Impedance Control of a Powered Knee-Ankle Prosthesis. [PDF]

IEEE Trans Neural Syst Rehabil Eng, 2023
Welker CG, Best TK, Gregg RD.
europepmc   +1 more source