Results 91 to 100 of about 176,914 (339)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Variable-number tandem repeat markers for Mycobacterium intracellulare genotyping: comparison to the 16S rRNA gene sequencing

Journal of Infection in Developing Countries, 2017
Introduction: Characterizing Mycobacterium intracellulare responsible for nontuberculous mycobacterial (NTM) infections may aid in controlling outbreaks.
Kaisen Chen, Yangyi Zhang, Yiping Peng
doaj   +1 more source

A new minisatellite-based scheme for the global surveillance of Xanthomonas citri pv. citri, the causal agent of Asiatic Citrus Canker. : S12O12 [PDF]

, 2012
Xanthomonas citri pv. citri (Xcc), the causal agent of Asiatic Citrus Canker, is an internationally major bacterial pathogen currently not reported from countries in the Mediterranean basin, including the EU. Some pathological diversity among strains was
Escalon, Aline, Gagnevin, Lionel, Gordon, Jonathan, Guérin, Fabien, Leduc, Alice, Magne, Maxime, Pruvost, Olivier, Vernière, Christian, Vital, Karine   +8 more
core  

Association between amygdala reactivity and a dopamine transporter gene polymorphism [PDF]

, 2014
Essential for detection of relevant external stimuli and for fear processing, the amygdala is under modulatory influence of dopamine (DA). The DA transporter (DAT) is of fundamental importance for the regulation of DA transmission by mediating reuptake ...
Appel, L, Bani, M, Bergman, O, Bettica, P, Eriksson, E, Faria, V, Ferrell, R E, Fredrikson, M, Furmark, T, Hariri, A R, Henningsson, S, Linnman, C, Manuck, S B, Nikolova, Y S, Pich, E M, Westberg, L, Åhs, F   +16 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Novel motif of variable number of tandem repeats in TPMT  promoter region and evolutionary association of variable number of tandem repeats with TPMT*3  alleles [PDF]

Pharmacogenomics, 2018
SNPs in the gene for TPMT exemplify one of the most successful translations of pharmacogenomics into clinical practice. This study explains the correlation between common SNPs and variable number of tandem repeats (VNTR) in promoter of the gene.We determined VNTR polymorphisms, as well as TPMT*2 and TPMT*3 SNPs and TPMT activity in Slovenian and ...
Urbančič, Dunja, Šmid, Alenka, Stocco, Gabriele, Decorti, Giuliana, Mlinarič-Raščan, Irena, Karas Kuželički, Nataša   +5 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Tuberculosis in Swiss captive Asian elephants: microevolution of Mycobacterium tuberculosis characterized by multilocus variable-number tandem-repeat analysis and whole-genome sequencingle-number tandem-repeat analysis and whole-genome sequencing [PDF]

, 2017
Zoonotic tuberculosis is a risk for human health, especially when animals are in close contact with humans. Mycobacterium tuberculosis was cultured from several organs, including lung tissue and gastric mucosa, of three captive elephants euthanized in a ...
Coscolla, Mireia, Feldmann, Julia, Friedel, Ute, Gagneux, Sebastien, Ghielmetti, Giovanni, Loiseau, Chloé, Ruetten, Maja, Steinmetz, Hanspeter W., Stucki, David   +8 more
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

No evidence of a significant role for CTLA-4 in multiple sclerosis [PDF]

, 2006
Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore
Compston, A, Deans, J, Hensiek, A, Maranian, M, Roxburgh, R, Sawcer, S, Seaman, S, Yeo, T   +7 more
core