Results 1 to 10 of about 29,122 (264)

Functional Domains of Autoimmune Regulator (AIRE) Modulate INS-VNTR Transcription in Human Thymic Epithelial Cells*

Journal of Biological Chemistry, 2016
INS-VNTR (insulin-variable number of tandem repeats) and AIRE (autoimmune regulator) have been associated with the modulation of insulin gene expression in thymus, which is essential to induce either insulin tolerance or the development of insulin ...
A. E. Sparks, Chia-Chen Chen, M. Breslin, Michael S. Lan   +3 more
semanticscholar   +1 more source

Development of a hierarchical variable-number tandem repeat typing scheme for Mycobacterium tuberculosis in China.

PLoS ONE, 2014
Molecular typing based on variable-number tandem repeats (VNTR) analysis is a promising tool for identifying transmission of Mycobacterium tuberculosis. However, the currently proposed 15- and 24-locus VNTR sets (VNTR-15/24) only have limited resolution ...
Tao Luo, Chongguang Yang, Yu Pang, Yanlin Zhao, Jian Mei, Qian Gao   +5 more
doaj   +1 more source

A 40-bp VNTR polymorphism in the 3′-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism

Behavioral and Brain Functions, 2015
BackgroundADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels.
O. Šerý, I. Paclt, I. Drtílková, P. Theiner, M. Kopečková, P. Zvolský, V. Balcar   +6 more
semanticscholar   +1 more source

Molecular Typing of Mycobacterium Tuberculosis Complex by 24-Locus Based MIRU-VNTR Typing in Conjunction with Spoligotyping to Assess Genetic Diversity of Strains Circulating in Morocco

PLoS ONE, 2015
Background Standard 24-locus Mycobacterial Interspersed Repetitive Unit Variable Number Tandem Repeat (MIRU-VNTR) typing allows to get an improved resolution power for tracing TB transmission and predicting different strain (sub) lineages in a community.
Nada Bouklata, P. Supply, Sanae Jaouhari, R. Charof, F. Seghrouchni, K. Sadki, Y. El Achhab, C. Nejjari, A. Filali-Maltouf, Ouafae Lahlou, R. Elaouad   +10 more
semanticscholar   +1 more source

Clustering of Beijing genotype Mycobacterium tuberculosis isolates from the Mekong delta in Vietnam on the basis of variable number of tandem repeat versus restriction fragment length polymorphism typing

BMC Infectious Diseases, 2013
Background In comparison to restriction fragment length polymorphism (RFLP) typing, variable number of tandem repeat (VNTR) typing is easier to perform, faster and yields results in a simple, numerical format.
Huyen Mai NT, Kremer Kristin, Lan Nguyen TN, Buu Tran N, Cobelens Frank GJ, Tiemersma Edine W, de Haas Petra, van Soolingen Dick   +7 more
doaj   +1 more source

Genetic Diversity of Mycobacterium tuberculosis Isolates from Assam, India: Dominance of Beijing Family and Discovery of Two New Clades Related to CAS1_Delhi and EAI Family Based on Spoligotyping and MIRU-VNTR Typing

PLoS ONE, 2015
Tuberculosis (TB) is one of the major public health concerns in Assam, a remote state located in the northeastern (NE) region of India. The present study was undertaken to explore the circulating genotypes of Mycobacterium tuberculosis complex (MTBC) in ...
K. R. Devi, R. Bhutia, S. Bhowmick, K. Mukherjee, J. Mahanta, K. Narain   +5 more
semanticscholar   +1 more source

Characterization of three VNTR systems at D21S112

Genomics, 1992
D21S112 is a highly polymorphic marker on the long arm of chromosome 21. Our analysis of this locus indicated the presence of three VNTR systems. We estimated the heterozygosity of each system and sequenced one of the repetitive regions. Utilizing PCR, we demonstrated that the sequenced VNTR is responsible for the system with the highest level of ...
N, Takaesu, S, Newfeld, T, Hassold
openaire   +2 more sources

VNTR analysis reveals unexpected genetic diversity within Mycoplasma agalactiae, the main causative agent of contagious agalactia

BMC Microbiology, 2008
Background Mycoplasma agalactiae is the main cause of contagious agalactia, a serious disease of sheep and goats, which has major clinical and economic impacts. Previous studies of M.
Ayling Roger D, Loria Guido, Lawes Joanna R, Churchward Colin P, McAuliffe Laura, Nicholas Robin AJ   +5 more
doaj   +1 more source

Effect of study design and setting on tuberculosis clustering estimates using Mycobacterial Interspersed Repetitive Units-Variable Number Tandem Repeats (MIRU-VNTR): a systematic review

BMJ Open, 2015
Objectives To systematically review the evidence for the impact of study design and setting on the interpretation of tuberculosis (TB) transmission using clustering derived from Mycobacterial Interspersed Repetitive Units-Variable Number Tandem Repeats ...
Jessica Mears, I. Abubakar, T. Cohen, Timothy D McHugh, P. Sonnenberg   +4 more
semanticscholar   +1 more source

Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC. [PDF]

PLoS ONE, 2011
Variability in cystic fibrosis (CF) lung disease is partially due to non-CFTR genetic modifiers. Mucin genes are very polymorphic, and mucins play a key role in the pathogenesis of CF lung disease; therefore, mucin genes are strong candidates as genetic ...
Xueliang Guo, Rhonda G Pace, Jaclyn R Stonebraker, Clayton W Commander, Anthony T Dang, Mitchell L Drumm, Ann Harris, Fei Zou, Dallas M Swallow, Fred A Wright, Wanda K O'Neal, Michael R Knowles   +11 more
doaj   +1 more source