Results 21 to 30 of about 21,570 (220)

A VNTR Regulates miR-137 Expression Through Novel Alternative Splicing and Contributes to Risk for Schizophrenia

Scientific Reports, 2019
The MIR137HG gene encoding microRNA-137 (miR-137) is genome-wide associated with schizophrenia (SZ), however, the underlying molecular mechanisms remain unknown.
Ashley Pacheco, R. Berger, R. Freedman, A. Law   +3 more
semanticscholar   +1 more source

Analysis of Vibrio cholerae Genotype Stability at Low Temperature and Nutrients Deficiency

Проблемы особо опасных инфекций, 2016
Objective is an experimental study of the low temperature and nutrient deficiency effects on the stability of Vibrio cholerae El Tor genetic loci complex.Materials and methods. The stability of the genetic loci (i.e. the basic pathogenicity genes; genome
L. V. Mironova, Zh. Yu. Khunkheeva, E. A. Basov, A. S. Ponomareva, S. K. Mitkeeva, S. V. Balakhonov   +5 more
doaj   +1 more source

Single molecule real time sequencing in ADTKD-MUC1 allows complete assembly of the VNTR and exact positioning of causative mutations

Scientific Reports, 2018
Recently, the Mucin-1 (MUC1) gene has been identified as a causal gene of autosomal dominant tubulointerstitial kidney disease (ADTKD). Most causative mutations are buried within a GC-rich 60 basepair variable number of tandem repeat (VNTR), which ...
Andrea Wenzel, J. Altmueller, A. Ekici, B. Popp, K. Stueber, H. Thiele, Alois Pannes, S. Staubach, E. Salido, P. Nuernberg, R. Reinhardt, A. Reis, P. Rump, F. Hanisch, M. T. Wolf, M. Wiesener, B. Huettel, B. Beck   +17 more
semanticscholar   +1 more source

A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression

Frontiers in Molecular Neuroscience, 2022
We describe the characterisation of a variable number tandem repeat (VNTR) domain within intron 1 of the amyotrophic lateral sclerosis (ALS) risk gene CFAP410 (Cilia and flagella associated protein 410) (previously known as C21orf2), providing insight ...
Jack N. G. Marshall, Alexander Fröhlich, Li Li, Li Li, Abigail L. Pfaff, Abigail L. Pfaff, Ben Middlehurst, Thomas P. Spargo, Thomas P. Spargo, Thomas P. Spargo, Alfredo Iacoangeli, Alfredo Iacoangeli, Alfredo Iacoangeli, Bing Lang, Ammar Al-Chalabi, Ammar Al-Chalabi, Sulev Koks, Sulev Koks, Vivien J. Bubb, John P. Quinn   +19 more
doaj   +1 more source

MOLECULAR CHARACTERIZATION OF MYCOBACTERIUM TUBERCULOSIS STRAINS CIRCULATING IN THE URAL REGION, RUSSIA

Инфекция и иммунитет, 2014
. Overall 178 Mycobacterium tuberculosis isolates recovered in 2009–2011 from newly diagnosed epidemiologically unlinked to TB patients in the Ural region of Russia have been studied.
T. V. Umpeleva, M. A. Kravchenko, N. I. Eremeeva, A. A. Vyazovaya, O. V. Narvskaya   +4 more
doaj   +1 more source

Role of MIRU-VNTR and spoligotyping in assessing the genetic diversity of Mycobacterium tuberculosis in Henan Province, China

BMC Infectious Diseases, 2018
BackgroundTuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB).
Jie Shi, D. Zheng, Yankun Zhu, Xiao-guang Ma, Shaohua Wang, Hui Li, J. Xing   +6 more
semanticscholar   +1 more source

Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2017
BACKGROUND/OBJECTIVES We have recently described copy number variants (CNVs) of the human carboxyl-ester lipase (CEL) gene, including a recombined deletion allele (CEL-HYB) that is a genetic risk factor for chronic pancreatitis.
M. Dalva, Khadija El Jellas, S. Steine, B. Johansson, Monika Ringdal, Janniche Torsvik, H. Immervoll, D. Hoem, Felix Laemmerhirt, P. Simon, M. Lerch, S. Johansson, P. Njølstad, F. Weiss, K. Fjeld, A. Molven   +15 more
semanticscholar   +1 more source

Analysis of MNS16A VNTR polymorphic sequence variations of the TERT gene and associated risk for development of bladder cancer

Current Urology, 2021
. Background:. The MNS16A variable number tandem repeat (VNTR) polymorphism of the human telomerase reverse transcriptase (hTERT) gene acts as a regulator of hTERT promoter activity and has been shown to have a role in the predisposition toward various ...
Iqra Anwar, Arshad A. Pandith, Mohammad S. Wani, Hyder Mir, Meena Godha, Aabid Koul, Zafar A. Shah, Usma Manzoor, Ina Amin, Iqbal Qasim   +9 more
doaj   +1 more source

IL‐1RA VNTR and IL‐1α 4845G>T polymorphisms and risk of idiopathic male infertility in Iranian men: A case–control study and an in silico analysis

Andrologia, 2018
This study aimed to investigate the association of IL‐1RA VNTR and IL‐1α 4845G>T polymorphisms with idiopathic male infertility followed by an in silico analysis. In a case–control study, we collected blood samples from 230 infertile and 230 healthy men.
Tayyebeh Zamani-Badi, H. Nikzad, M. Karimian   +2 more
semanticscholar   +1 more source

Development of VNTR-Based Test System for V. cholerae Typing

Проблемы особо опасных инфекций, 2011
Analysis of VNTRs was used for typing of V. cholerae strains deposited in microbial culture collection of 48 Central Research Institute. The most informative loci and flanking primers were chosen, VNTR profiles were compiled, and allele variability ...
Ya. A. Kibirev, I. V. Darmov, M. A. Loginova, I. V. Marakulin, D. A. Chukhlantsev, T. I. Dormidontova, S. L. Kuznetsov, A. V. Kuznetsovskii   +7 more
doaj   +1 more source