Results 21 to 30 of about 12,118 (162)

Development of a hierarchical variable-number tandem repeat typing scheme for Mycobacterium tuberculosis in China.

PLoS ONE, 2014
Molecular typing based on variable-number tandem repeats (VNTR) analysis is a promising tool for identifying transmission of Mycobacterium tuberculosis. However, the currently proposed 15- and 24-locus VNTR sets (VNTR-15/24) only have limited resolution ...
Tao Luo, Chongguang Yang, Yu Pang, Yanlin Zhao, Jian Mei, Qian Gao   +5 more
doaj   +1 more source

Analysis of MNS16A VNTR polymorphic sequence variations of the TERT gene and associated risk for development of bladder cancer

Current Urology, 2021
. Background:. The MNS16A variable number tandem repeat (VNTR) polymorphism of the human telomerase reverse transcriptase (hTERT) gene acts as a regulator of hTERT promoter activity and has been shown to have a role in the predisposition toward various ...
Iqra Anwar, Arshad A. Pandith, Mohammad S. Wani, Hyder Mir, Meena Godha, Aabid Koul, Zafar A. Shah, Usma Manzoor, Ina Amin, Iqbal Qasim   +9 more
doaj   +1 more source

Clustering of Beijing genotype Mycobacterium tuberculosis isolates from the Mekong delta in Vietnam on the basis of variable number of tandem repeat versus restriction fragment length polymorphism typing

BMC Infectious Diseases, 2013
Background In comparison to restriction fragment length polymorphism (RFLP) typing, variable number of tandem repeat (VNTR) typing is easier to perform, faster and yields results in a simple, numerical format.
Huyen Mai NT, Kremer Kristin, Lan Nguyen TN, Buu Tran N, Cobelens Frank GJ, Tiemersma Edine W, de Haas Petra, van Soolingen Dick   +7 more
doaj   +1 more source

Extreme enrichment of VNTR-associated polymorphicity in human subtelomeres: genes with most VNTRs are predominantly expressed in the brain [PDF]

Translational Psychiatry, 2020
AbstractThe human genome harbors numerous structural variants (SVs) which, due to their repetitive nature, are currently underexplored in short-read whole-genome sequencing approaches. Using single-molecule, real-time (SMRT) long-read sequencing technology in combination with FALCON-Unzip, we generated a de novo assembly of the diploid genome of a 115 ...
Linthorst, Jasper, Meert, Wim, Hestand, Matthew S., Korlach, Jonas, Vermeesch, Joris Robert, Reinders, Marcel J.T., Holstege, Henne   +6 more
openaire   +4 more sources

VNTR analysis reveals unexpected genetic diversity within Mycoplasma agalactiae, the main causative agent of contagious agalactia

BMC Microbiology, 2008
Background Mycoplasma agalactiae is the main cause of contagious agalactia, a serious disease of sheep and goats, which has major clinical and economic impacts. Previous studies of M.
Ayling Roger D, Loria Guido, Lawes Joanna R, Churchward Colin P, McAuliffe Laura, Nicholas Robin AJ   +5 more
doaj   +1 more source

Characterization of the COL2A1 VNTR Polymorphism

Genomics, 1993
The variable number of tandem repeat (VNTR) region 3' to the collagen type II gene (COL2A1) was amplified in vitro by the polymerase chain reaction. Subsequent high-resolution gel electrophoresis showed that the five earlier reported alleles could be further subtyped.
E S, Berg, B, Olaisen
openaire   +2 more sources

METHODOLOGICAL APPROACHES TO MYCOBACTERIUM TUBERCULOSIS GENOTYPING FOR EVOLUTIONARY AND EPIDEMIOLOGICAL RESEARCH

Инфекция и иммунитет, 2014
. Current genome evolution of Mycobacterium tuberculosis is marked by virtual absence of the lateral gene transfer leading to the clonal population of this species consisting of separate genetic families. Standard typing method of M. tuberculosis (IS6110-
I. V. Mokrousov
doaj   +1 more source

Development of a technique for molecular typing of Bacillus anthracis strains using new VNTR and INDEL markers

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Bacillus anthracis, the pathogen of a particularly dangerous zoonotic disease known as anthrax, requires strict epidemiological control and is characterized by high genetic homogeneity, which necessitates the development of genotyping ...
Grigorii A. Pechkovskii, Evgeny I. Eremenko, Alla G. Ryazanova, Sergey V. Pisarenko, Nikolay A. Shapakov, Lyudmila Yu. Aksenova, Olga V. Semenova, Lyudmila D. Timchenko, Alexander N. Kulichenko   +8 more
doaj   +1 more source

Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma

İstanbul Medical Journal, 2019
Introduction:It has been shown that the host immune response and chronic inflammation could play a role as important risk factors for cancer. Oral squamous cell carcinoma (OSCC) is a common cancer worldwide. In this study, we aimed to evaluate the impact
Özge Gümüşay, Ayşe Feyda Nursal, Serbülent Yiğit, Akın Tekcan, Tuba Öz   +4 more
doaj   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source