MNS16A Tandem Repeats Minisatellite of Human Telomerase Gene and Cancer Risk: A Meta-Analysis [PDF]
PLoS ONE, 2013 BACKGROUND: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and ...
Xiaoping Miao, Jie Yan, Jiao Lou
exaly +5 more sources
Pytrf: a python package for finding tandem repeats from genomic sequences [PDF]
BMC BioinformaticsBackground Tandem repeats (TRs) are major sources of genetic variation and important genetic markers. Their expansions are not only involved in gene expression regulation but also associated with many nervous system diseases and cancers.
Lianming Du +6 more
doaj +2 more sources
DNA Fingerprinting and Cloning of Hypervariable Minisatellite Repeats in Salmonids [PDF]
Canadian Journal of Fisheries and Aquatic Sciences, 1994 We used heterologous Jeffreys' 33.6 core sequence and microsatellites (CAC)5and (CA)12as probes and compared them with probes based on the minisatellite sequences from tilapia (Oreochromis niloticus) and Atlantic salmon (Salmo salar) in fingerprinting assays.
Welt, M +3 more
exaly +3 more sources
Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus litoralis DNA polymerase. [PDF]
Nucleic Acids Res, 2005 Repeating DNA sequences, such as telomeres, centromeres, and micro- and mini-satellites, comprise 50% of the genome and play important roles in regulatory and pathogenic mechanisms. In order to study structures and functions of such repeating sequences, it is important to have simple and efficient methods for making them in vitro. Here, we describe the
Hartig JS, Kool ET.
europepmc +5 more sources
Exploring the Genetic Variability of Gmelina arborea Roxb. in Mexico with Molecular Markers to Establish an Efficient Improvement Program [PDF]
PlantsMelina (Gmelina arborea Roxb.) is a tree native to Asia, whose timber is not utilized in that region for a variety of reasons. However, the tree’s fast growth and extensive range of applications have increased its acceptance in other world’regions.
Marynor E. Ortega-Ramírez +6 more
doaj +2 more sources
MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer [PDF]
Carcinogenesis, 2011 Telomerase reactivation and expression of human telomerase gene [human telomerase reverse transcriptase (hTERT)] are hallmarks of unlimited proliferation potential of cancer cells. A polymorphic tandem repeats minisatellite of hTERT gene, termed MNS16A was reported to influence hTERT expression.
Andreas Baierl +2 more
exaly +4 more sources
IGS Minisatellites Useful for Race Differentiation in Colletotrichum lentis and a Likely Site of Small RNA Synthesis Affecting Pathogenicity. [PDF]
PLoS ONE, 2015 Colletotrichum lentis is a fungal pathogen of lentil in Canada but rarely reported elsewhere. Two races, Ct0 and Ct1, have been identified using differential lines. Our objective was to develop a PCR-probe differentiating these races.
Jonathan Durkin +4 more
doaj +1 more source
Variation of serine-aspartate repeats in membrane proteins possibly contributes to staphylococcal microevolution. [PDF]
PLoS ONE, 2012 Tandem repeats (either as microsatellites or minisatellites) in eukaryotic and prokaryotic organisms are mutation-prone DNA. While minisatellites in prokaryotic genomes are underrepresented, the cell surface adhesins of bacteria often contain the ...
Jing Cheng, Huping Xue, Xin Zhao
doaj +1 more source
Sequence-based estimation of minisatellite and microsatellite repeat variability [PDF]
Genome Research, 2007 Variable tandem repeats are frequently used for genetic mapping, genotyping, and forensics studies. Moreover, variation in some repeats underlies rapidly evolving traits or certain diseases. However, mutation rates vary greatly from repeat to repeat, and as a consequence, not all tandem repeats are suitable genetic markers or interesting unstable ...
Legendre, Matthieu +3 more
openaire +2 more sources
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. [PDF]
PLoS Genetics, 2009 In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still poorly understood.
Cyril Ribeyre +7 more
doaj +1 more source