Human Chromosomal Fragile Site FRA16B Is an Amplified AT-Rich Minisatellite Repeat [PDF]
Cell, 1997 Fragile sites are nonstaining gaps in chromosomes induced by specific tissue culture conditions. They vary both in population frequency and in the culture conditions required for induction. Folate-sensitive fragile sites are due to expansion of p(CCG)n trinucleotide repeats; however, the relationship between sequence composition and the chemistry of ...
Robert Ian Richards +2 more
exaly +8 more sources
Variable tandem repeats accelerate evolution of coding and regulatory sequences. [PDF]
Annual Review of Genetics, 2010 Genotype-to-phenotype mapping commonly focuses on two major classes of mutations: single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we discuss an underestimated third class of genotypic variation: changes in microsatellite and
Rita Gemayel +3 more
semanticscholar +2 more sources
Transfusion Medicine, 1999 Since the cloning in 1990 of cDNA corresponding to mRNA transcribed at the blood group ABO locus, polymorphisms at the ABO locus and phenotype-genotype correlation have been analysed by several investigators.
Irshaid, Chester, Olsson
semanticscholar +3 more sources
Attempts to detect retrotransposition and de novo deletion of Alus and other dispersed repeats at specific loci in the human genome [PDF]
, 2001 Dispersed repeat elements contribute to genome instability by de novo insertion and unequal recombination between repeats. To study the dynamics of these processes, we have developed single DNA molecule approaches to detect de novo insertions at a single
Monckton, D.G. +2 more
core +7 more sources
Sequence-based estimation of minisatellite and microsatellite repeat variability. [PDF]
Genome Research, 2007 Variable tandem repeats are frequently used for genetic mapping, genotyping, and forensics studies. Moreover, variation in some repeats underlies rapidly evolving traits or certain diseases. However, mutation rates vary greatly from repeat to repeat, and as a consequence, not all tandem repeats are suitable genetic markers or interesting unstable ...
M. Legendre +3 more
semanticscholar +3 more sources
MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer. [PDF]
Carcinogenesis, 2011 Telomerase reactivation and expression of human telomerase gene [human telomerase reverse transcriptase (hTERT)] are hallmarks of unlimited proliferation potential of cancer cells. A polymorphic tandem repeats minisatellite of hTERT gene, termed MNS16A was reported to influence hTERT expression.
P. Hofer +8 more
semanticscholar +4 more sources
Variation of serine-aspartate repeats in membrane proteins possibly contributes to staphylococcal microevolution. [PDF]
PLoS ONE, 2012 Tandem repeats (either as microsatellites or minisatellites) in eukaryotic and prokaryotic organisms are mutation-prone DNA. While minisatellites in prokaryotic genomes are underrepresented, the cell surface adhesins of bacteria often contain the ...
Jing Cheng, Huping Xue, Xin Zhao
doaj +1 more source
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. [PDF]
PLoS Genetics, 2009 In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still poorly understood.
Cyril Ribeyre +7 more
doaj +1 more source
Investigation of distal repetitive sequences in the genus allium [PDF]
, 2009 PhDThe telomere is a DNA/protein structure required to maintain the ends of linear chromosomes. Usually the DNA component comprises a highly conserved tandemly repeated minisatellite sequence.
Chester, Michael
core +3 more sources
DNA secondary structure forming at minisatellite repeat unit sequences [PDF]
Nucleic Acids Symposium Series, 2006 The lengths of simple repeat sequences are generally unstable or polymorphic; that is, they are highly variable with respect to the numbers of tandem repeats. To determine the structural features that cause such variability, we examined a minisatellite DNA isolated from the yellow fin sea bream Acanthopagrus latus.
Takeshi, Haku +5 more
openaire +2 more sources