Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat [PDF]
Cell, 1997 Fragile sites are nonstaining gaps in chromosomes induced by specific tissue culture conditions. They vary both in population frequency and in the culture conditions required for induction.
Hobson, Lynne +32 more
core +6 more sources
Oncogene, 2003 Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death.
Jean-Charles Soria +2 more
exaly +2 more sources
IGS Minisatellites Useful for Race Differentiation in Colletotrichum lentis and a Likely Site of Small RNA Synthesis Affecting Pathogenicity. [PDF]
PLoS ONE, 2015 Colletotrichum lentis is a fungal pathogen of lentil in Canada but rarely reported elsewhere. Two races, Ct0 and Ct1, have been identified using differential lines. Our objective was to develop a PCR-probe differentiating these races.
Jonathan Durkin +4 more
doaj +1 more source
Sequence-based estimation of minisatellite and microsatellite repeat variability [PDF]
Genome Research, 2007 Variable tandem repeats are frequently used for genetic mapping, genotyping, and forensics studies. Moreover, variation in some repeats underlies rapidly evolving traits or certain diseases. However, mutation rates vary greatly from repeat to repeat, and as a consequence, not all tandem repeats are suitable genetic markers or interesting unstable ...
Legendre, Matthieu +3 more
openaire +2 more sources
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. [PDF]
PLoS Genetics, 2009 In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still poorly understood.
Cyril Ribeyre +7 more
doaj +1 more source
Fragile sites, chromosomal lesions, tandem repeats, and disease
Frontiers in Genetics, 2022 Expanded tandem repeat DNAs are associated with various unusual chromosomal lesions, despiralizations, multi-branched inter-chromosomal associations, and fragile sites.
Mila Mirceta +7 more
doaj +1 more source
DNA secondary structure forming at minisatellite repeat unit sequences [PDF]
Nucleic Acids Symposium Series, 2006 The lengths of simple repeat sequences are generally unstable or polymorphic; that is, they are highly variable with respect to the numbers of tandem repeats. To determine the structural features that cause such variability, we examined a minisatellite DNA isolated from the yellow fin sea bream Acanthopagrus latus.
Takeshi, Haku +5 more
openaire +2 more sources
Molecular mining of alleles in water buffalo Bubalus bubalis and characterization of the TSPY1 and COL6A1 genes. [PDF]
PLoS ONE, 2011 BACKGROUND: Minisatellites are an integral part of eukaryotic genomes and show variation in the complexity of their organization. Besides their presence in non-coding regions, a small fraction of them are part of the transcriptome, possibly participating
Sudeep Kumar +3 more
doaj +1 more source
Repeat instability at human minisatellites arising from meiotic recombination [PDF]
The EMBO Journal, 1998 Little is known about the role of meiotic recombination processes such as unequal crossover in driving instability at tandem repeat DNA. Methods have therefore been developed to detect meiotic crossovers within two different GC-rich minisatellite repeat arrays in humans, both in families and in sperm DNA.
Jeffreys, AJ, Neil, DL, Neumann, R
openaire +3 more sources
Biologia Plantarum, 2016 Moth orchids (Phalaenopsis) are among the top-traded blooming potted plants in the world. To explore mitochondrial DNA (mtDNA) markers for species identification, we located simple sequence repeats in the mtDNA of Phalaenopsis aphrodite subsp.
B. -Y. Lin +9 more
doaj +1 more source