Results 21 to 30 of about 176,914 (339)

Variable number tandem repeats – Their emerging role in sickness and health [PDF]

Experimental Biology and Medicine, 2021
Understanding the mechanisms regulating tissue specific and stimulus inducible regulation is at the heart of understanding human biology and how this translates to wellbeing, the ageing process, and disease progression. Polymorphic DNA variation is superimposed as an extra layer of complexity in such processes which underpin our individuality and are ...
Jack NG Marshall, Ana Illera Lopez, Abigail L Pfaff, Sulev Koks, John P Quinn, Vivien J Bubb   +5 more
openaire   +3 more sources

Multiple-locus variable number tandem repeat analysis for Streptococcus pneumoniae: comparison with PFGE and MLST. [PDF]

PLoS ONE, 2011
In the era of pneumococcal conjugate vaccines, surveillance of pneumococcal disease and carriage remains of utmost importance as important changes may occur in the population.
Karin E M Elberse, Sónia Nunes, Raquel Sá-Leão, Han G J van der Heide, Leo M Schouls   +4 more
doaj   +1 more source

Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats. [PDF]

PLoS Genetics, 2014
Tandem repeats are common in eukaryotic genomes, but due to difficulties in assaying them remain poorly studied. Here, we demonstrate the utility of Nanostring technology as a targeted approach to perform accurate measurement of tandem repeats even at ...
Manisha Brahmachary, Audrey Guilmatre, Javier Quilez, Dan Hasson, Christelle Borel, Peter Warburton, Andrew J Sharp   +6 more
doaj   +1 more source

Targeted Genotyping of Variable Number Tandem Repeats with adVNTR [PDF]

Genome Research, 2017
AbstractWhole Genome Sequencing is increasingly used to identify Mendelian variants in clinical pipelines. These pipelines focus on single nucleotide variants (SNVs) and also structural variants, while ignoring more complex repeat sequence variants. We consider the problem of genotypingVariable Number Tandem Repeats(VNTRs), composed of inexact tandem ...
Bakhtiari, Mehrdad, Shleizer-Burko, Sharona, Gymrek, Melissa, Bansal, Vikas, Bafna, Vineet   +4 more
openaire   +4 more sources

High-throughput typing of Staphylococcus aureus by amplified fragment length polymorphism (AFLP) or multi-locus variable number of tandem repeat analysis (MLVA) reveals consistent strain relatedness [PDF]

, 2008
This study investigates aspects of the general assumption that, in bacteria, genetic variation in functionally-constrained genomic regions accumulates at a lower rate than in regions of hypermutability such as DNA repeat loci.
Belkum, A.F. (Alex) van, François, P., Herzig, S., Melles, D.C. (Damian), Schouls, L.M., Schrenzel, J., Verbrugh, H.A. (Henri)   +6 more
core   +15 more sources

Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing of Mycobacterium tuberculosis

Journal of Clinical Microbiology, 2006
Molecular typing based on 12 loci containing variable numbers of tandem repeats of mycobacterial interspersed repetitive units (MIRU-VNTRs) has been adopted in combination with spoligotyping as the basis for large-scale, high-throughput genotyping of ...
P. Supply, Caroline Allix, Sarah Lesjean, M. Cardosooelemann, S. Rüsch-Gerdes, Eve Willery, Evgueni Savine, P. de Haas, H. van Deutekom, S. Roring, P. Bifani, N. Kurepina, B. Kreiswirth, C. Sola, Nalin Rastogi, V. Vatin, M. Gutierrez, Maryse Fauville, S. Niemann, R. Skuce, K. Kremer, C. Locht, D. van Soolingen   +22 more
semanticscholar   +1 more source

VNTRDB: a bacterial variable number tandem repeat locus database [PDF]

Nucleic Acids Research, 2007
Variable number tandem repeat-PCR (VNTR-PCR) is a novel method developed for molecular typing of microorganisms. This method has proven useful in epidemiological studies in medical microbiology. Although hundreds of bacterial genomes have been sequenced, variable number tandem repeats (TRs) derived from comparative genome analyses are scarce.
Chang, Chia-Hung, Chang, Yu-Chung, Underwood, Anthony, Chiou, Chien-Shun, Kao, Cheng-Yan   +4 more
openaire   +3 more sources

Genetic Diversity and Genotype Distribution of Erwinia amylovora in Korea [PDF]

The Plant Pathology Journal
Erwinia amylovora, first identified in 1793 in Hudson Valley (New York, USA), has a genome size of 3.7–4.0 Mb. E. amylovora bacterial strains are classified based on the infecting hosts: the Amygdaloideae-infecting (AI) group, targeting apple and pear ...
Hyeonheui Ham, Se-Weon Lee, Yong Hwan Lee   +2 more
doaj   +1 more source

Multiple Locus Variable number of tandem repeat Analysis : a molecular genotyping tool for Paenibacillus larvae [PDF]

, 2016
American Foulbrood, caused by Paenibacillus larvae, is the most severe bacterial disease of honey bees (Apis mellifera). To perform genotyping of P.larvae in an epidemiological context, there is a need of a fast and cheap method with a high resolution ...
Alippi, Alippi, Antunez, Ash, Ash, Bassi, Belkum, Belkum, Buhlmann, Bui, Chan, Djordjevic, Djukic, Dobbelaere, Gelfand, Genersch, Genersch, Genersch, Genersch, Girard, Graaf, Graaf, Heyndrickx, Katznelson, Klevytska, Lindstedt, Lindstrom, Lindstrom, Loncaric, Malachowa, Mazars, Morrissey, Neuendorf, Qin, Schafer, Stratilo, Techaruvichit, Torres-Cruz, U'Ren, Vogler, Wu   +40 more
core   +2 more sources

Mucin Variable Number Tandem Repeat Polymorphisms and Severity of Cystic Fibrosis Lung Disease: Significant Association with MUC5AC [PDF]

, 2011
Variability in cystic fibrosis (CF) lung disease is partially due to non-CFTR genetic modifiers. Mucin genes are very polymorphic, and mucins play a key role in the pathogenesis of CF lung disease; therefore, mucin genes are strong candidates as genetic ...
AM Watson, Ann Harris, Anthony T. Dang, C Taylor, CK Heazlewood, Clayton W. Commander, Dallas M. Swallow, DJ Schaid, DJ Thornton, Du, F Escande, F Silva, FA Wright, Fei Zou, Fred A. Wright, G Caramori, GR Cutting, HJ Kirkbride, J Fowler, JA Voynow, Jaclyn R. Stonebraker, JC Barrett, JC Fowler, JR Gum Jr, K Engelmann, K Mitsuta, K Rousseau, K Rousseau, LE Vinall, LE Vinall, LE Vinall, LE Vinall, LL Vanscoy, MA Seibold, MC Rose, Michael R. Knowles, Mitchell L. Drumm, ML Drumm, MO Henke, MR Knowles, Rhonda G. Pace, S Kirkham, S Purcell, SZ Hasnain, Tobias Eckle, W Ng, Wanda K. O'Neal, WS Pratt, XueLiang Guo   +48 more
core   +14 more sources