Results 41 to 50 of about 52,446 (303)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Design and Analysis of a Serial Position-Controlled Variable Stiffness Rotating Mechanism Based on Multi-Stage Torsional Compliant Mechanisms

Actuators
This work presents the design and experimental validation of a position-controlled rotating mechanism featuring multi-stage variable stiffness. Before designing the overall mechanism, three different compliant mechanisms, based on flexible beams, are ...
Kai Wen, Guanglei Wu
doaj   +1 more source

Bio-Inspired Aquatic Propulsion Mechanism Using Viscoelastic Fin Containing Fiber Composite Shear Thickening Fluid

Biomimetics, 2023
Many propulsion mechanisms utilizing elastic fins inspired by the caudal fins of aquatic animals have been developed. However, these elastic fins possess a characteristic whereby the rigidity required to achieve propulsion force and speed increases as ...
Shunichi Kobayashi, Kousuke Sugiyama
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Influence of friction bearings on the frequency response of a variable stiffness mechanism

, 2022
This contribution examines a variable stiffness mechanism that is intended for the use as a boundary element in vibration tests. The mechanism consists of two antagonistic nonlinear springs guided along the central axis.
Heyden, Emil, Krause, Dieter, Mas, V., Matthiesen, Sven, Lindenmann, Andreas   +4 more
core  

Design and Analysis of a Novel Variable Stiffness Joint for Robot

MATEC Web of Conferences, 2018
As people pay more attention to the safety of human-robotic interaction, the flexibility of machine joints is becoming more and more important. To address the needs of future robotic applications, many kinds of variable stiffness mechanisms have been ...
Zhang Xiang, Capehart Twan, Moore Carl A.   +2 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Torque and workspace analysis for flexible tendon driven mechanisms

, 2010
Tendon driven mechanisms have been considered in robotic design for several decades. They provide lightweight end effectors with high dynamics. Using remote actuators it is possible to free more space for mechanics or electronics.
Chalon, Maxime, Hirzinger, Gerd, Thomas Wimböck, Wimboeck, Thomas, Gerd Hirzinger, Maxime Chalon   +5 more
core   +1 more source

Low-cost variable stiffness joint design using translational variable radius pulleys [PDF]

, 2018
Robot joints are expected to be safe, compliant, compact, simple and low-cost. Gravity compensation, zero backlash, energy efficiency and stiffness adjustability are some desired features in the robotic joints.
Bayraktar, Ertugrul, Boyraz Baykas, Pinar, Boyraz, Pınar, Yigit, Cihat Bora,, Yigit, Cihat Bora, Boyraz Baykas, Pinar,, Boyraz, Pinar, Bayraktar, Ertugrul,   +7 more
core   +1 more source

Design and analysis of spring parallel variable stiffness actuator based on antagonistic principle

, 2019
Human-machine collaboration is an inevitable development trend of robots, and the variable stiffness joints of robots has been increasingly investigated by researchers. The variable stiffness joint based on the antagonism principle has received extensive
Liu JG(刘金国), Liu XG(刘霞刚), Liu, Yuwang, Liu, Jinguo, Liu YW(刘玉旺), Yuan, Zhongqiu, Liu, Xiagang, Yuan ZQ(袁忠秋)   +7 more
core   +2 more sources