Results 201 to 210 of about 3,198,668 (318)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Ecological ubiquity and phylogeny drive nestedness in phages-bacteria networks and shape the bacterial defensome. [PDF]

PLoS Pathog
Feltin C, Piry S, Moury B, Chateau L, Berthier K, Jacobs JM, Butchacas J, Fenske L, Ebeling-Koning L, Smits THM, Morris CE, Torres-Barceló C.   +11 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Human movement patterns predict task-unrelated thought. [PDF]

PLoS One
Wong AY, Charles AE, Mills C, Stergiou N, Likens AD.   +4 more
europepmc   +1 more source

A Novel Terminal Sliding Mode Variable Structure Model Reference Adaptive System Observer for Permanent Magnet Synchronous Motors [PDF]

Yan Bai, Lei Zhang, Xiang-Min Meng, Jing Bai, Guang Han   +4 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Study on urban passenger transport carbon reduction pathways based on system dynamics. [PDF]

Sci Rep
Liu R, Liu N.
europepmc   +1 more source

RBFNN Variable Structure Controller for MIMO System and Application to Ship Rudder/Fin Joint Control

, 2014
Han Zhen, Hairong Xiao
openalex   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Analytical solutions and chaotic insights into the Hirota-Maccari system. [PDF]

Sci Rep
Usman T, Ullah MS.
europepmc   +1 more source