Results 41 to 50 of about 599,512 (246)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Synchronization of Chaotic Systems with Dead Zones via Fuzzy Adaptive Variable-Structure Control

open access: yesComplexity, 2021
This work is devoted to solving synchronization problem of uncertain chaotic systems with dead zones. Based on the Lyapunov stability theorems, by using fuzzy inference to estimate system uncertainties and by designing effective fuzzy adaptive ...
Yongbing Huangfu, Kaijuan Xue
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Sliding mode-based active disturbance rejection control for vehicle steer-by-wire systems

open access: yesIET Cyber-Physical Systems, 2018
This study presents a sliding mode-based active disturbance rejection control (SMADRC) scheme for a steer-by-wire (SbW) system in road vehicles. First, a plant model that describes the mechanical dynamics of the SbW system is elaborated, where the ...
Zhe Sun   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Steady-state control strategy of VSC-HVDC transmission system based on full-order terminal sliding mode control method

open access: yesThe Journal of Engineering, 2019
High-voltage direct current (HVDC) techniques play an important role in the power transmission, especially for the distance district. For the HVDC, control system is necessary to the operation of flexible transmission system, so it is significant to ...
Xuemei Zheng   +3 more
doaj   +1 more source

Integral sliding mode control for back-to-back converter of DFIG wind turbine system

open access: yesThe Journal of Engineering, 2020
In this study, an integral sliding mode control approach for controlling the power electronics converters of a doubly-fed induction generator (DFIG) wind turbine system is presented.
Adel Merabet   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Integral sliding mode control for non-linear systems with mismatched uncertainty based on quadratic sliding mode

open access: yesThe Journal of Engineering, 2015
In this study, uncertainty and disturbance compensations are addressed for non-linear systems by an integral sliding mode (ISM) design. It is divided into two steps for implementation of the ISM control.
Xiaoyu Zhang
doaj   +1 more source

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