Results 81 to 90 of about 7,497,770 (317)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Methods of variance component estimation [PDF]
Czech Journal of Animal Science, 2006 Estimation of variance components is a method often used in population genetics and applied in animal breeding. Even experienced population geneticists nowadays feel lost if confronted with the huge set of different methods of variance component estimation. Especially because there exists no uniformly best method, a decision which method should be used
O. Mašata, D. Rasch
openaire +2 more sources
Quantifying variance components in ecological models based on expert opinion
, 2011 Summary 1. Expert opinion is often relied on to build ecological models when empirical data are absent. Despite widespread use, expert models often ignore uncertainty though it may affect predictions. We assess the importance of such uncertainty for
Christina A. Czembor +3 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
On testing variance components in ANOVA models [PDF]
, 2000 In this paper we derive asymptotic x 2 - tests for general linear hypotheses on variance components using repeated variance components models. In two examples, the two-way nested classification model and the two-way crossed classification model with ...
Hartung, Joachim, Knapp, Guido
core +1 more source
, 2010 Genomic imprinting has been thought to play an important role in seed development in flowering plants. Seed in a flowering plant normally contains diploid embryo and triploid endosperm.
Cui, Yuehua, Li, Gengxin
core +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Multiplicative main cultivar effects in Czech official winter wheat trials 1976-2005
Czech Journal of Genetics and Plant Breeding, 2007 98 winter wheat cultivars, tested by the Czech Plant Variety Office in 554 trials between 1976 and 2005, were analysed for breeding progress, yielding capacity and behaviour in particular environments.
Erik Schwarzbach +2 more
doaj +1 more source
Confidence regions for variance ratios in variance components models [PDF]
Statistical mechanics for constructing confidence intervals for variance ratios in balanced and unbalanced experimental ...
Al-Barhawe, A. S., Hartley, H. O.
core +1 more source
Exploration and reduction of data using principal component analysis [PDF]
, 2002 In a data set with two variables only, a scatterplot between the two variables can be easily plotted to represent the data visually. When the number of variables in the data set is large, however, it is more difficult to represent visually. The method of
Buhagiar, Anton
core