Results 91 to 100 of about 8,438 (230)

Trypanosome mRNAs share a common 5' spliced leader sequence. [PDF]

, 1984
A 5'-terminal leader sequence of 35 nucleotides was found to be present on multiple trypanosome RNAs. Based on its representation in cDNA libraries, we estimate that many, if not all, trypanosome mRNAs contain this leader. This same leader was originally
Agabian, N, Nelson, RG, Parsons, M, Watkins, KP   +3 more
core  

The effects of symmetry on the dynamics of antigenic variation

, 2012
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen.
A Fässler, A Marcello, B Adams, B Fiedler, C Jones, C Newbold, C Stockdale, CA Pinto, CMR Turner, CO Buckee, CO Buckee, DG Aronson, DJ Smith, DL Martin, H Farkas, I Stewart, IM Rouzine, JD Barry, JD Murray, JHP Dawes, JL Mitchell, JL Muñoz-Jordán, JR Gog, JW Swift, KA Lythgoe, KB Blyuss, Konstantin B. Blyuss, KW Deitsch, LJ Abu-Raddad, LM Pecora, M Dellnitz, M Golubitsky, M Golubitsky, M Golubitsky, M Golubitsky, M Recker, M Recker, M Recker, M Recker, M Recker, MGM Gomes, MJ Gardner, O Bagasra, P Ashwin, P Ashwin, P Borst, P De Leenheer, P Hagblom, P Minaev, PL Buono, R Antia, S Gupta, S Gupta, S Gupta, S Kyes, S Lutenschlager, SA Frank, SA Frank, SH Strogatz, V Calvez, Y Jiang, Z Agur   +61 more
core   +1 more source

The interaction of Trypanosoma brucei with antibodies to variant surface glycoproteins

Journal of Cell Science, 1990
ABSTRACT Binding to Trypanosoma brucei of polyvalent IgMs and IgGs, monoclonal IgGs and Fabi fragments of monoclonal IgGs specific for exposed epitopes of T. brucei variant surface glycoproteins (VSGs) was monitored by both immunofluorescence and immu-nocytochemistry. All antibodies and antibody fragments, were uniformly distributed over
Webster, P., Russo, D.C.W., Black, Samuel J.   +2 more
openaire   +2 more sources

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, Volume 292, Issue 19, Page 5105-5129, October 2025.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

Hidden Markov Models for Gene Sequence Classification: Classifying the VSG genes in the Trypanosoma brucei Genome

, 2015
The article presents an application of Hidden Markov Models (HMMs) for pattern recognition on genome sequences. We apply HMM for identifying genes encoding the Variant Surface Glycoprotein (VSG) in the genomes of Trypanosoma brucei (T.
Alvarez-Valin, Fernando, Basterrech, Sebastián, Guerberoff, Gustavo, Mesa, Andrea   +3 more
core   +1 more source

Phosphatase activity characterization on the surface of intact bloodstream forms of Trypanosoma brucei [PDF]

, 2003
Procyclic forms of Trypanosoma brucei possess a phosphatase activity on their external cell surface. This activity, while it dephosphorylates [P-32]phosphocasein, is inhibited weakly by NaF and tartrate but strongly by vanadate. in this work, we describe
Aoyama, Hiroshi, Fernandes, Eloise Cedro, Granjeiro, José Mauro, Meyer-Fernandes, José Roberto, Taga, Eulázio Mikio   +4 more
core   +2 more sources

Crystallization of amino-terminal domains and domain fragments of variant surface glycoproteins from Trypanosoma brucei brucei.

Journal of Biological Chemistry, 1988
Crystals were produced from variant surface glycoproteins (VSG) of Trypanosoma brucei brucei antigenic variants MITat 1.2, 1.6, and ILTat 1.22, 1.23, 1.24, 1.25, and 1.26.
P. Metcalf, J. Down, M. Turner, D. Wiley
semanticscholar   +1 more source

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics [PDF]

, 2012
Trypanosoma brucei survives in mammals through antigenic variation, which is driven by RAD51-directed homologous recombination of Variant Surface Glycoproteins (VSG) genes, most of which reside in a subtelomeric repository of >1000 silent genes. A key
Alsford, Anna Trenaman, Ayoub, Becker, Bennett, Bork, Bringaud, Brough, Callejas, Carlos R. Machado, Carreira, Carreira, Chung, Claire Hartley, Danielle G. Passos-Silva, Daniels, Davies, Davies, Dobson, Dray, Dumont, Esashi, Esashi, Futamura, Genois, Giloni, Glover, Hartley, Hashimoto, Heyer, Jackson, Jeyasekharan, Kim, Kim, Ko, Kojic, Kojic, Kojic, Lee, Lisby, Lo, Lord, Marcello, Marko Prorocic, Marmorstein, McCulloch, McKean, McKean, Melville, Mizuta, Moniek van den Hoek, Morrison, Munday, Oyola, Park, Petalcorin, Proudfoot, Raz, Regis-da-Silva, Renzette, Richard McCulloch, Robinson, Saeki, Schlacher, Shivji, Tarsounas, Tarsounas, Vink, Volodymyr Nechyporuk-Zloy, Yu, Zeiner, Zhou   +71 more
core   +1 more source

Transcriptomic analysis of N-terminal mutated Trypanosoma cruzi UBP1 knockdown underlines the importance of this RNA-binding protein in parasite development.

PLoS Neglected Tropical Diseases
BackgroundDuring its life cycle, the human pathogen Trypanosoma cruzi must quickly adapt to different environments, in which the variation in the gene expression of the regulatory U-rich RNA-binding protein 1 (TcUBP1) plays a crucial role.
Karina B Sabalette, Vanina A Campo, José R Sotelo-Silveira, Pablo Smircich, Javier G De Gaudenzi   +4 more
doaj   +1 more source

SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes [PDF]

, 2019
SUMOylation is a post¿translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG).
Alvarez, Vanina E., Andrés-León, Eduardo, Bart, Jean M., Boehm, Cordula, Field, Mark C., Iribarren, Paula A., López-Farfán, Diana, Navarro, Miguel, Rojas-Barros, Domingo, Saura, Andreu, Vidal-Cobo, Isabel   +10 more
core   +5 more sources