An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction [PDF]
, 2016 Trypanosoma brucei rhodesiense and T. brucei gambiense, the causative agents of Human African Trypanosomiasis, are transmitted by tsetse flies. Within the vector, the parasite undergoes through transformations that prepares it to infect the human host ...
Alicia Ponte-Sucre
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Structural analysis of the variable major proteins of Borrelia hermsii. [PDF]
, 1983 Borrelia hermsii undergoes spontaneous antigenic variation in vivo and in vitro. Serotype specificity is associated with expression of one of a family of molecular weight-variable proteins, the pI proteins.
Barbour, AG, Barrera, O, Judd, RC
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Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei [PDF]
, 2014 We have discovered a new mechanism of monoallelic gene expression that links antigenic variation, cell cycle, and development in the model parasite Trypanosoma brucei. African trypanosomes possess hundreds of variant surface glycoprotein (VSG) genes, but
Batram, Christopher +4 more
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Characterization of an African trypanosome mutant refractory to lectin-induced death [PDF]
, 2015 Incubation of African trypanosomes with the lectin concanavalin A (conA) leads to alteration in cellular DNA content, DNA degradation, and surface membrane blebbing.
Acosta Serrano, Alvaro
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The interaction of Trypanosoma congolense with endothelial cells [PDF]
, 2017 Factors which affect adhesion of cultured Trypanosoma congolense bloodstream forms to mammalian feeder cells have been examined. Using an in vitro binding assay, the initial events following interaction of trypanosomes with bovine aorta endothelial (BAE)
Frame, I., Hemphill, A., Ross, C. A.
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Trypanosoma brucei: Release of variant surface glycoprotein during the parasite life cycle
Experimental Parasitology, 1986 African trypanosome variant surface antigen, which was released from the Trypanosoma brucei parasite at two stages in its life cycle, has been characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the presence of 4 M urea. Variant surface antigen released as exoantigen into the bloodstream of infected rats resembled the soluble ...
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The genetics and genomics of Trypanosoma cruzi [PDF]
, 2007 Trypanosoma cruzi is a kinetoplastid parasite that causes Chagas disease. Trypanosomes are unusual organisms in many aspects of its genetics and molecular and cellular biology and considered a paradigm of the exception of the rule in the eukaryotic ...
Vazquez, Martin Pablo
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Bidirectional silencing of RNA polymerase I transcription by a strand switch region in Trypanosoma brucei [PDF]
, 2017 The procyclin genes in Trypanosoma brucei are transcribed by RNA polymerase I as part of 5-10 kb long polycistronic transcription units on chromosomes VI and X.
Burkard, Gabriela Schumann +3 more
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Variant surface glycoprotein synthesis and cell cycle progression in Trypanosoma brucei
, 2011 The unicellular eukaryote Trypanosoma brucei causes African Sleeping sickness and multiplies extracellularly in the bloodstream of the infected host. The parasite evades antibody-mediated lysis by switching its Variant Surface Glycoprotein (VSG) coat. Blocking VSG synthesis results in an abrupt growth inhibition and a precise pre-cytokinesis cell cycle
Wand, N, Wand, Nadina
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