Results 161 to 170 of about 1,835,894 (312)

Commentary: Meta-Analysis and Structural Dynamics of the Emergence of Genetic Variants of SARS-CoV-2

Frontiers in Medicine, 2021
Sara Haddadi, Mehdi Mirsaeidi
doaj   +1 more source

Adjusting for Medication Use in GWAS and Its Impact on Mendelian Randomisation Analyses: An Example of Systolic Blood Pressure in UK Biobank. [PDF]

Genet Epidemiol
Yap AJY, Hanson AL, Griffith GJ, Sanderson E.   +3 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Diagnostic Yield of Expanded Multigene Testing in Hereditary Polyposis Syndromes: Functional Characterization of Clinically Relevant Variants. [PDF]

Cancer Genomics Proteomics
Martín EM, Arranz-Ledo M, Aras EL, Hernández AO, Alonso RF, Sanz LH, Martín NM, Sanz MI, Domínguez MD.   +8 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Guardians of splicing: quality control mechanisms of snRNA variants. [PDF]

Genes Dev
Mohan HM, Parker R.
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Machine learning-guided dual optimization of the substrate specificity and thermostability of yeast alcohol dehydrogenase. [PDF]

Biotechnol Biofuels Bioprod
Ogawa Y, Kondo A, Shirai T.
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Multimodal <i>KCNQ1</i> Variant-Effect Maps Define Ion Channel Mechanisms and Disease Risk. [PDF]

Circulation
Harvey ML, Osborn E, Lancaster MC, Smith JE, Shen Q, Abe TA, Cai R, Muhammad A, Kannankeril R, Yang T, Calandranis ME, Blackwell DJ, Dolder RE, Aldridge JL, Fleming MR, Blair MA, Soria E, O'Sullivan JW, Davogustto G, Kroncke BM, MacRae CA, Knollmann BC, Roth FP, Parikh VN, Ashley EA, Vandenberg JI, Ng CA, Roden DM, Glazer AM.   +28 more
europepmc   +1 more source