Results 201 to 210 of about 1,835,894 (312)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

RASSF2 Under the Computational Microscope: Prediction of Destabilizing Missense Variants. [PDF]

Biology (Basel)
Al-Eitan LN, Abusalem MT, Alghamdi MA.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Integrative Bioinformatics Analysis Incorporating Artificial Intelligence and Machine Learning Identifies Putative Pathogenic HNF1B Missense Variants Associated with HNF1B-MODY. [PDF]

Int J Mol Sci
Aldharee H.
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

A multicenter whole-genome sequencing cohort of bleomycin-induced pneumonitis in predominantly clinically low-risk patients. [PDF]

Mol Genet Genomics
Hitchen N, Handel EE, Leslie C, Di Ciaccio PR, Joshua A, Ardolino L, Grimison P, Honeyball F, Tran B, McCarthy L, Milliken S, Viiala N, Gangatharan S, Bilmon I, Zhang AY, Lewin J, Marx G, Murphy C, Trinh A, Wong N, Goldstein L, Kummerfeld S, Hobbs M, Barnet MB.   +23 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Whole-Exome Sequencing in Patients with Tooth Agenesis and Neurodevelopmental Disorders: A Descriptive Case Series. [PDF]

Int J Mol Sci
Calì F, Musumeci A, Vinci M, L'Episcopo S, Bartolone M, Gloria A, Ferri R, Treccarichi S, Fallea A.   +8 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Genotype-phenotype analysis in 333 individuals with heterozygous variants in NFKB1. [PDF]

J Hum Immun
Armbruster SM, Caballero-Oteyza A, Bartsch O, Lorenzini T, Abolhassani H, Chan S, González Granado LI, Garcia-Bustos V, Cabañero Navalon MD, Fathi N, Rezaei N, Fusaro M, Colobran R, Boztug K, Proietti M, Grimbacher B.   +15 more
europepmc   +1 more source