Results 241 to 250 of about 1,835,894 (312)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The population frequency of predicted pathogenic variants in the genes associated with Autosomal Dominant Polycystic Liver Disease (ADPLD) and kidney cysts. [PDF]

PLoS One
Varughese S, Huang M, Savige J.
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Long-read sequencing enables high-accuracy mitochondrial heteroplasmy detection in Parkinson's disease. [PDF]

BMC Genomics
Lüth T, Schaake S, Much C, Belyea MM, Seibler P, Grünewald A, May P, Klein C, Weissensteiner H, Trinh J.   +9 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Integrating pangenome and imputation framework reveals structural variants affecting stature and milk composition traits in French dairy cattle. [PDF]

J Anim Sci Biotechnol
Naji MM, Sorin V, Grohs C, Fritz S, Klopp C, Faraut T, Boichard D, Boussaha M, Sanchez MP.   +8 more
europepmc   +1 more source

Saturation mutagenesis enables RAD51D clinical variant interpretation and identifies distinct biochemical functions. [PDF]

Nat Commun
Darrah KE, Hemker SL, Rawal Y, Goff NJ, Parker PS, Ganesan GS, Stratton CM, Oppenheimer KG, Roberts E, Glick E, Banks N, Kumar AK, Casadei S, Snyder MW, Milliron KJ, Merajver SD, Dias AM, Nathanson KL, Domchek SM, Starita LM, Olsen SK, Sung P, Kitzman JO, Bernstein KA.   +23 more
europepmc   +1 more source

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Variant angina: More variants of the variant

The American Journal of Cardiology, 1979
As experience increases with “variant” angina, originally described by Prinzmetal et al.,’ it becomes more difficult to define this condition as a single clinical entity. Probably the best overall operational definition is that of angina associated with S-T segment elevations not precipitated by any increase in myocardial metabolic demands. However, it
openaire   +2 more sources