Results 41 to 50 of about 1,572,926 (319)

Performance of genotype imputation for rare variants identified in exons and flanking regions of genes. [PDF]

open access: yes, 2011
Genotype imputation has the potential to assess human genetic variation at a lower cost than assaying the variants using laboratory techniques. The performance of imputation for rare variants has not been comprehensively studied.
Margaret Gelder Ehm   +50 more
core   +1 more source

Crystallographic Texture Analysis of As-Built and Heat-Treated Ti6Al4V (ELI) Produced by Direct Metal Laser Sintering

open access: yesCrystals, 2020
This paper reports on an investigation of crystallographic texture of as-built and heat-treated Ti6Al4V (ELI) produced by direct metal laser sintering (DMLS). The texture analyses were conducted using electron backscatter diffraction (EBSD).
Amos Muiruri   +2 more
doaj   +1 more source

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization [PDF]

open access: yes, 2012
Introduction: In recent genome-wide association studies for psoriatic arthritis (PsA) and psoriasis vulgaris, common coding variants in the TRAF3IP2 gene were identified to contribute to susceptibility to both disease entities.
Maria Apel   +14 more
core   +1 more source

Of variants and vaccines [PDF]

open access: yesCell, 2021
In this issue of Cell, Bushman et al. show how more transmissible variants, even if they do not escape immunity, can be strongly selected during the early pandemic. This explains the dynamics of past SARS-CoV-2 variants, but as immunity increases, it is difficult to predict what will emerge next.
Nathan D. Grubaugh, Sarah Cobey
openaire   +2 more sources

Variants

open access: yes, 2015
The variants files- both the unfiltered variants as well as the variants used in the ABC ...
Thibaut Capblancq (3289932)   +7 more
core   +1 more source

Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians : ADCY5 and GLIS3 variants may predispose to type 2 diabetes [PDF]

open access: yes, 2011
Background: The Meta-Analysis of Glucose and Insulin related traits Consortium (MAGIC) recently identified 16 loci robustly associated with fasting glucose, some of which were also associated with type 2 diabetes.
Hydrie, MZI   +37 more
core   +1 more source

JWES: a new pipeline for whole genome/exome sequence data processing, management, and gene‐variant discovery, annotation, prediction, and genotyping

open access: yesFEBS Open Bio, 2021
Whole genome and exome sequencing (WGS/WES) are the most popular next‐generation sequencing (NGS) methodologies and are at present often used to detect rare and common genetic variants of clinical significance.
Zeeshan Ahmed   +3 more
doaj   +1 more source

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis [PDF]

open access: yes, 2013
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10−4).
International Ibd Genetics Consortium   +999 more
core   +1 more source

Raman Molecular Fingerprints of SARS‐CoV‐2 British Variant and the Concept of Raman Barcode

open access: yesAdvanced Science, 2022
The multiple mutations of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus have created variants with structural differences in both their spike and nucleocapsid proteins.
Giuseppe Pezzotti   +11 more
doaj   +1 more source

Respiratory viruses interacting with cells: the importance of electrostatics

open access: yesFrontiers in Microbiology, 2023
The COVID-19 pandemic has rekindled interest in the molecular mechanisms involved in the early steps of infection of cells by viruses. Compared to SARS-CoV-1 which only caused a relatively small albeit deadly outbreak, SARS-CoV-2 has led to fulminant ...
Daniel Lauster   +4 more
doaj   +1 more source

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