Results 71 to 80 of about 1,835,894 (312)
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background
Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter +17 morewiley +1 more sourceHundreds of variants clustered in genomic loci and biological pathways affect human height [PDF]
, 2010 Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1)Lawrence, Robert W, Preuss, M., Pastinen, Tomi, Cusi, D., Ridker, P.M., P. Elliott, D. Absher, Kwan, T, Assimes, Themistocles L., Heid, I. M., Ingelsson, E., Elosua, R., Jianjun Liu, Sanna, Serena, Hall, A.S. (Alistair), Boerwinkle, E., Anneli Pouta, Huikuri, H.V. (Heikki), Qi, L., Knowles, JW, Hayes, Richard B, Palmer, L.J., Hicks, Andrew A, D. J. Hunter, Hengstenberg, Christian, Palmer, C., Nelis, M, Mari Nelis, Glazer, NL, A. S. Hall, A. U. Jackson, Rafelt, S, Sanders, A. R., A. T. Hattersley, Smith, AV, Kaprio, Jaakko, Antti Jula, Qi, Lu, Soumya Raychaudhuri, Monda, Keri L., Uitterlinden, André G, Turchin, MC, Perry, J.R., Ardlie, K. G., Lawrence, Robert W., O´Connell, J.R., S. Kathiresan, Geus, E.J., Sambrook, Jennifer G., Stefansson, K, Willemsen, G.A.H.M. (Gonneke), O'Donnell, CJ, Palmer, Lyle J., Frayling, Timothy M., M. den Heijer, Wichmann, H.E. (Heinz Erich), Bhangale, T. (Tushar), Jianxin Shi, Montgomery, G.W., Igl, W., Harris, T.B. (Tamara), Haritunians, T. (Talin), Geus, E. J., Quertermous, T., Waterworth, D. (Dawn), Boomsma, D. I., Atwood, Larry D, Sanders, A.R., Smit, J.H., Meurs, J.B.J., Kilpeläinen, T.O., Munroe, PB, Cupples, L.A. (Adrienne), Pastinen, T., A. R. Wood, Mary F. Feitosa, Larry D. Atwood, Liu, Jianjun, Cusi, D. (Daniele), Qi, L, Peters, M. J., Rivadeneira, F, S. H. Wild, K. B. Jacobs, Tony Kwan, Raychaudhuri, Soumya, Eero Kajantie, Gyllensten, Ulf,, J. Hua Zhao, Strachan, David P., Schreiber, S., Hall, AS, M. J. Caulfield, Markku S. Nieminen, Kwan, T., Johnson, T, Penninx, B.W.J.H., V. Steinthorsdottir, Rudan, I. (Igor), Workalemahu, Tsegaselassie, Shaun Purcell, Kajantie, E, Kocher, T, O’Donnell, Christopher J., Palmer, Cameron, K. G. Ardlie, et al., Smith, A.V. (Albert Vernon), Knowles, J. W., Willem H. Ouwehand, Ouwehand, Willem H, Hirschhorn, J. N., Benjamin F. Voight, Zillikens, M. C., Tammesoo, M.L., Dixon, A.L., Mark Lathrop, G., Alice M. Arnold, Robertson, N. R., Morris, Andrew, C. M. Lindgren, Vitart, Veronique, Völzke, H. (Henry), Johannes Kettunen, Iribarren, Carlos, Johansson, Åsa,, Voight, B. F., Kolcic, I. (Ivana), Martin, Nicholas G, A. Johansson, Musk, AW, Cupples, L.A., Kähönen, M., Ketkar, S, Lettre, G, Yurii S. Aulchenko, Erdmann, Je., Morris, AP, Christian Hengstenberg, Wright, A.F., E. Salvi, Robert W. Lawrence, Kilpeläinen, TO, J. Duan, Jaakko Tuomilehto, Riddertrale, M., Robertson, N.R., Thompson, JR, C. Rivolta, Ana Marusic, Charles C. White, Lachlan Coin, Gibson, Q., Gudbjartsson, Daniel, Altmaier, EL, Wareham, N.J., Weedon, Michael N., T. O. Kilpeläinen, Haiqing, Shen, Ulf Gyllensten, Peter P. Pramstaller, Wild, S.H. (Sarah), Katja K. Aben, Erdmann, Jeanette, Ngwa, JS, Chatterjee, N, I. M. Heid, van Ommen, GJ, D. R. Nyholt, David S. Siscovick, Mosley Jr, T.H., Weyant, R.J., Salvi, E. (Erika), E. Widen, Zgaga, L, Heath, A.C., Johan G. Eriksson, Illig, T., Hall, Per, Rafelt, Suzanne, Kilpelainen, T. O., Nyholt, D.R., Barbara McKnight, Visscher, PM, M. Mangino, Monda, K.L., Hicks, Andrew A., Jackson, A.U., U. Sovio, J. r. Mosley TH, Ben Oostra, Oskari Kilpeläinen, Tuomas, Pietiläinen, Kirsi H, Wilson, James F, Huikuri, Heikki V, Jennie Hui, Peters, Marjolein, Tönjes, A. (Anke), Völzke, H, Parker, AN, Ridderstråle, M. (Martin), Liu, J. (Jianjun), Schmidt, C.O., Ripatti, S., E. L. Altmaier, de Geus, EJC, Heard-Costa, Nancy L., Daniel Gudbjartsson, Erdmann, J, Wright, AF, Aulchenko, Y.S., Hottenga, J.J., A. Petersmann, Joel N. Hirschhorn, Farrall, M. (Martin), Iris M. Heid, Palmer, LJ, Wood, Andrew R, Parker, A. N., Cornelia M. van Duijn, Hicks, A.A., Beckmann, Jacques S, Geus, Eco JC, Almgren, P. (Peter), Hirschhorn, J.N. (Joel), Hua Zhao, Jing, Waterworth, D., Florian Ernst, Melander, O, Jacques S. Beckmann, Stumvoll, M. (Michael), Thorsteinsdottir, U, Polasek, Ozren, Eco J. C. Geus, Hui, J.N., Jarvelin, MR, Dixon, Anna L., Salomaa, V. (Veikko), Perry, J. R., Eriksson, J.G., Thorsteinsdottir, U. (Unnur), Groop, L. (Leif), Winkler, T.W., Lorentzon, Mattias,, Stefan Schreiber, Jackson, Anne U, Boucher, G. (Gabrielle), Walters, G. Bragi, Steinthorsdottir, V. (Valgerdur), Wiklund, F. (Fredrik), Mueller, M, Julius Suh Ngwa, Shi, JX, Sanders, Alan R, A. S. Havulinna, Ferreira, T., Barroso, Ines, Goddard, M.E. (Michael), Collins, FS, Chatterjee, N., Thor Aspelund, E. Kajantie, Heard-Costa, NL, Mosley, Tom H., Jr., Zhao, JH, D. F. Levinson, R. C. Kaplan, Kaplan, R.C., David J. Hunter, Tom H. Mosley Jr, Pramstaller, PP, Shi, J., Mosley, Tom H., Rissanen, A, Wilmar Igl, Pouta, A. (Anneli), Hayes, Richard B., Visscher, Peter M., Schmidt, Carsten Oliver, Kutalik, Z. (Zoltán), Esko, T. (Tõnu), Barroso, I.E. (Inês), Elisabeth Widen, Elliott, P., J. Suh Ngwa, North, KE, L. Qi, Nyholt, DR, Wheeler, Eleanor, Hayes, RB, Jonathan P. Tyrer, Pietilainen, K.H. (Kirsi Hannele), McCarthy, M.I. (Mark), Marjo-Riitta Jarvelin, Spector, Timothy D, Duijn, C.M. (Cornelia) van, C. Gieger, Grundberg, E. (Elin), Gejman, P.V. (Pablo), Weedon, M. N., Suh Ngwa, J., Mägi, R., Beilby, John P, Kiemeney, L.A.L.M., White, C. C., Elosua, Roberto, L. Coin, N. L. Glazer, Tuomilehto, J., Toenjes, A, A. R. Sanders, U. Thorsteinsdottir, L. Adrienne Cupples, Deloukas, P, Vedantam, S. (Sailaja), Smit, Jan H., Hunter, D.J. (David), Aben, K. K., Launer, L. J., Serena Sanna, N. W. Rayner, Heid, I.M. (Iris), R. Mägi, Ngwa, J.S., Chasman, D.I. (Daniel), Robertson, Neil R, E. Ingelsson, Cameron Palmer, Lango Allen, H., Mohlke, K.L., K. K. Aben, Campbell, Harry, T. Bhangale, Rayner, Nigel W., Jan H. Smit, Voight, Benjamin F, C. C. White, Allen, Hana Lango, Shi, J. (Jianxin), Segrè, A.V. (Ayellet), Atwood, L.D. (Larry), van Ommen, G.J., Leena Peltonen, Arnold, A. M., Feitosa, M.F. (Mary Furlan), Zgaga, L. (Lina), M. Kayser, Bergmann, S, F. Ernst, Lawrence, RW, Kari Stefansson, A. M. Arnold, Steinthorsdottir, V., N. Amin, De Grandi, Alessandro, Hartikainen, AL, S. Schreiber, Hu, Frank B., Atwood, Larry D., Ripatti, S, J. P. Beilby, Hengstenberg, C, Lindgren, Cecilia M, Lorentzon, M. (Mattias), Erdmann, J. (Jeanette), Chasman, DI, L. Citterio, Fox, C.S., Vilmundur Gudnason, A. L. Dixon, Cristen J. Willer, Thompson, J.R., Michael A. Province, Lathrop, G.M. (Mark), van Ommen, G. J., Ivana Kolcic, Marusic, A, Wilson, J.F., Samani, N.J., Kathiresan, S, Petersmann, Astrid, Raitakari, O., Konig, I. R., T. Johnson, Coin, L. (Lachlan), D. Gudbjartsson, Junttila, M.J., Beilby, JP, Perry, JB, A. Dominiczak, M. Farrall, Soranzo, N., Zoltán Kutalik, Pouta, A., Widen, Elisabeth, Rotter, J. I., Walters, G.B. (Bragi), Perry, JR, Ernst, F, Perola, M. (Markus), Schmidt, CO, Wichmann, HE, Hall, P., Zagato, L., Preuss, Michael, Heather M. Stringham, Segrè, A.V., Pichler, Irene, Alistair S. Hall, Mark I. McCarthy, Bergman, R. N., Ken Sin Lo, Thompson, J.R. (John), Gabrielle Boucher, Kovacs, P, Spector, Timothy D., Bergmann, S., Kaprio, J, Smit, J.H. (Jan), Farrall, M., Frayling, Timothy M, Lokki, Marja Liisa, J. Erdmann, Heath, AC, Van Meurs, Joyce B J, Tyrer, J. P., Illig, T, Cupples, L Adrienne, Lo, Ken Sin, Aulchenko, Yurii S., Cupples, L. Adrienne, Peden, John F., Beckmann, J.S. (Jacques), Schreiber, S, Willemsen, G.; id_orcid, Prokopenko, I, Martina Müller, M. Juhani Junttila, Montgomery, Grant W, Citterio, L., Alessandro De Grandi, vVan Meurs, JBJ, Ferreira, T. (Teresa), Samani, Nilesh J, Peltonen, L. (Leena Johanna), Hattersley, Andrew T, Gudbjartsson, D, V. Mooser, Richard B. Hayes, Oliver Schmidt, C., P. M. Visscher, Boomsma, Dorret I., McArdle, W.L., Hirschhorn, J.N., T. Illig, Kovacs, Peter, Chatterjee, Nilanjan, Melander, O., A. G. Uitterlinden, Rissanen, Aila, Chen, C. (Constance), Zitting, P. (Paavo), H. Völzke, H. Alavere, Reedik Mägi, Hayward, Caroline, Hofman, A. (Albert), H. Watkins, Eriksson, J. G., Albert Hofman, Hao, K, Voight, B.F., Igl, Wilmar, Wild, S. H., Andrea Maschio, Boucher, G, T. Esko, Martin, N. G., Michael E. Goddard, Caulfield, MJ, Haritunians, T., Mosley, T. H., Lyle J. Palmer, Hottenga, J. J., Kaplan, Robert C, Hottenga, Jouke Jan, Kayser, Manfred, Nancy L. Heard-Costa, Hicks, AA, Aspelund, T, J. B. van Meurs, Cusi, D, Weedon, MN, Rayner, NW, Watkins, Hugh, Christian Gieger, Albrecht, E, Salem, R.M. (Rany), John R. B. Perry, Lathrop, G.M., Anna Dominiczak, Pellikka, Niina, C. Oliver Schmidt, Michael Boehnke, Jackson, A. U., Hayes, R.B., Spector, T.D., Hoffman, W. (Wolfgang), Loos, R.J.F., Park, Ju Hyun, Koiranen, M., J. Xu, G. W. Montgomery, L. Zagato, Balmforth, A. J., Kathiresan, Sekar, Wilson, JF, D.M. Cusi, Aulchenko, Yurii S, Perry, John RB, Province, Michael A, Andrew T. Hattersley, Knowles, J.W. (Joshua), Inke R. König, Rany M. Salem, Raychaudhuri, S, Abecasis, G. R., I. B. Borecki, S. Haiqing, Absher, D., T. Workalemahu, Johnson, T. (Toby), Maschio, A., Wilson, J.F. (James), Zillikens, MC, Altmaier, Elizabeth L., White, C.C., Meitinger, T. (Thomas), Weedon, M., Cooper, M.N. (Matthew), Rivolta, C. (Carlo), Verlaan, D. J., Peter Kovacs, Wheeler, E. (Eleanor), Robertson, N.R. (Neil), Fox, Caroline S, Nyholt, Dale, A. Vernon Smith, Gejman, P. V., Uda, M., Freimer, Nelson B, McArdle, W. L., Altmaier, E. L., M. N. Cooper, Rivadeneira Ramirez, F. (Fernando), McKnight, Barbara, V. Gudnason, Harris, Tamara B, Peters, M.J., Kathiresan, S., Sin Lo, K, Kettunen, Johannes, Campbell, H. (Harry), Wheeler, E., Caulfield, M. (Mark), L. J. Launer, Boehnke, M, Ruth J. F. Loos, Sanna, S, K. E. North, H.-Erich Wichmann, Wichmann, H.-E., van Duijn, C. M., Peltonen, L, Hu, F.B., Cooper, Matthew N, Suzanne Rafelt, Peden, J. (John), Borecki, Ingrid B., Kari E. North, Purcell, S., E. E. Schadt, M. N. Weedon, Huikuri, HV, Pellikka, N., Schadt, EE, A. L. Hartikainen, Vedantam, Sailaja, Eiriksdottir, G, Parker, A.N. (Alex), Nelis, M. (Mari), Perry, John R. B., Martin Farrall, Mooser, Vincent, Uitterlinden, AG, Illig, T. (Thomas), Gejman, Pablo V, Zillikens, M.C. (Carola), Sovio, U, Gieger, C, Chanock, Stephen J, Tamara B. Harris, Wichmann, H-Erich, Ouwehand, W.H. (Willem), Watkins, H., Aspelund, T. (Thor), Nelson B. Freimer, S. I. Berndt, Schlessinger, D., White, Charles C, Winkler, T.W. (Thomas), Altmaier, E.L., Mark J. Caulfield, Seppo Koskinen, Atwood, L. D., K. Hao, van Duijn, CM, Schadt, Eric E., Lawrence, R.W. (Robert), K. L. Mohlke, R. B. Hayes, Vandenput, Liesbeth, Paul M. Ridker, I. Rudan, Jarvelin, M.R., White, CC, Alan R. Sanders, Salem, Rany M., Chasman, Daniel I, R. W. Lawrence, Kocher, T. (Thomas), Wiklund, F., Kolcic, I., Havulinna, A.S., Kocher, T., Martin, NG, Ridker, P. M., L. J. Palmer, Johnson, T., Salomaa, V, Sambrook, J.G. (Jennifer), Schadt, HE, Jian Yang, Yang, Jian, Steinthorsdottir, V, J. R. O'Connell, Lambertus Kiemeney, Winkler, Thomas W., del Maschio, A, Kaplan, Lee M., Province, MA, Rivolta, C., Goddard, Michael E, Shuldiner, A.R., Paré, G., Workalemahu, T, Jula, A. (Antti), Soranzo, N. (Nicole), Nyholt, Dale R, Kaplan, R.C. (Robert), Nicola Glorioso, Koiranen, Markku, Uda, Manuela, John P. Beilby, Kiemeney, L, Prokopenko, Inga, Parker, Alex N., Oliver Schmidt, Carsten, Jian’an Luan, Peters, M.J. (Marjolein), Schmidt, C. O., Bergmann, Sven, A. N. Parker, Launer, Lenore J., Fox, C. S., Bergmann, S.M. (Sven), Ouwehand, W. H., Daniel I. Chasman, Wichmann, H. E., Loos, R.J.F. (Ruth), E. K. Speliotes, Wareham, N.J. (Nick), Nieminen, Markku S, McKnight, B. (Barbara), Salvi, E, Petersmann, A., Erika Salvi, Hunter, David J, Balmforth, AJ, Luan, Jian’an, Eriksson, J.G. (Johan), Kiemeney, L.A.L.M. (Bart), Alavere, H. (Helene), W. Igl, Esko, T, Almgren, Peter,, Rotter, Jerome I, Stefansson, K. (Kari), Vincent Mooser, Thompson, John R., N. J. Samani, Rissanen, A., Themistocles L. Assimes, P. Zitting, Erdmann, J., M. Nelis, Rioux, John D, Aulchenko, Y. S., van Meurs, J. B., Laitinen, J, A. A. Hicks, D. Waterworth, Paavo Zitting, Absher, Devin, Balmforth, Anthony J, G. J. van Ommen, Aben, Katja K., Pellikka, N. (Niina), Muller, M (Majon), A. Tönjes, Mika Kähönen, Uitterlinden, A. G., Berndt, S. I., Mooser, V. (Vincent), Kilpeläinen, Tuomas O, Frayling, T. M., Musk, A.W. (Arthur), W. H. Ouwehand, K. Sin Lo, Stefansson, H., Cupples, LA, Verlaan, Dominique J, Penninx, Brenda W., Zgaga, L., Beckmann, J.S., B. W. Penninx, Lettre, G. (Guillaume), A. Metspalu, Palmer, C. (Cameron), H. E. Wichmann, Jula, A, Penninx, B.W., McCarthy, M.I., Raychaudhuri, S., Polasek, O., Morris, Andrew P., Cupples, L. A., Junttila, M.J. (Juhani), P. M. Ridker, D. S. Siscovick, A. Hofman, Tyrer, JP, Koskinen, S., Marusic, A. (Ana), Collins, Francis S., Sinisalo, Juha, J. P. Tyrer, Weyant, R.J. (Robert), Niina Pellikka, Luan, Jian'an, Harris, TB, Allen, HL, T. Meitinger, Duan, J, Maschio, A, Deloukas, Panos, Christopher J. O’Donnell, Chanock, SJ, Wareham, Nicholas J., O'Connell, J.R., K. Estrada, Laitinen, Jaana, Salvi, E., Abecasis, GR, Anna L. Dixon, Oostra, B.A. (Ben), Allen, H., Perry, John B., Speliotes, EK, Ardlie, KG, Zhao, J.H., Berndt, SI, Koenig, IR, S. Ketkar, Vitart, V, N. Glorioso, M. Lorentzon, Liang, L. (Liming), Hayward, C, Borecki, I.B. (Ingrid), Assimes, Themistocles L, Berndt, S., Vedantam, S, Gyllensten, U. (Ulf), Lina Zgaga, Strachan, DP, G. Mark Lathrop, Kilpelaeinen, T.O., Speliotes, E., Glazer, N.L., Assimes, TL, Kettunen, J, Spector, TD, Schadt, Eric E, Igor Rudan, Elin Grundberg, Speliotes, E. K., Pablo V. Gejman, Smit, JH, W. L. McArdle, Lindgren, C. M., Siscovick, D.S. (David), Berndt, S.I., Hall, P, De Grandi, A, Nieminen, M.S., Glorioso, N., Quertermous, T. (Thomas), Hartikainen, A.L., Ommen, G.J. van, van Meurs, JB, Jouke-Jan Hottenga, Jacobs, K. B., Jacobs, K.B., L. Peltonen, Strachan, D. P., Henry Völzke, Lo, KS, Zagato, L, Hattersley, Andrew T., Jubao Duan, Tönjes, A, Peden, JF, Geus, Eco J C, Liang, L., T. Haritunians, Uda, M. (Manuela), Lehtimäki, T, Strachan, David P, M. L. Tammesoo, T. W. Winkler, Tammesoo, ML, R. Elosua, Abecasis, G.R. (Gonçalo), Speliotes, Elizabeth K, Spector, T. D., Tyrer, J.P., Samani, Nilesh J., R. J. Weyant, Campbell, H, Pichler, I. (Irene), Hofman, Bert, Wright, A. F., Watkins, H, Schadt, H.E., Kolcic, I, L. Kiemeney, Heath, A.C. (Andrew), Eriksson, Johan G., Kajantie, E., Hui, J. (Jennie), Nyholt, D.R. (Dale), Carola Zillikens, M., Feitosa, Mary F., Caroline S. Fox, Michael Stumvoll, Grundberg, Elin, Wood, A.R. (Andrew), Jorma Viikari, Sinisalo, J. (Juha), Heid, IM, Wichmann, H.-Erich, Kraft, P, Pouta, Anneli, Lorentzon, Mattias, Anke Tönjes, Park, J-H, Gieger, C., Surakka, I. (Ida), North, K.E. (Kari), Siscovick, DS, Iribarren, C, Raychaudhuri, S. (Soumya), Province, M.A., Ridker, Paul M, Arnold, Alice M, M. Müller, Verlaan, Dominique J., Elliott, P. (Paul), Ziegler, A. (Andreas), Sven Bergmann, Johansson, A, Lathrop, GM, Gudmar Thorleifsson, Coin, L, Peters, Marjolein J, J. Yang, O'Donnell, Christopher J., Richard N. Bergman, M. J. Peters, Jarvelin, M-R, Workalemahu, T., Tyrer, Jonathan P, Havulinna, Aki S, Beilby, J. P., Hartikainen, Anna Liisa, Mangino, Massimo, de Geus, E.J.C.; id_orcid, Lokki, M.L., Bragi Walters, G, Ohlsson, Claes,, Hicks, A.A. (Andrew), Irene Pichler, B. Oostra, Ripatti, S. (Samuli), Thompson, J. R., Wild, S.H., Gonneke Willemsen, Abecasis, Goncalo R., Mosley, TH, Albert Vernon Smith, Ferreira, T, Hamsten, A. (Anders), N. B. Freimer, Stefansson, K., Dominiczak, A, Eiriksdottir, G., van Meurs, J.B., Massimo Mangino, Aben, K.K., A. V. Segrè, Ouwehand, WH, Willemsen, G, Caroline Hayward, Harris, Tamara B., Hunter, David J., Van Duijn, Cornelia M., Boomsma, D.I.; id_orcid, Sanders, AR, O’Donnell, C.J., Sin Lo, Ken, Jarvelin, Marjo-Ritta, Groop, L. C., Harry Campbell, Goddard, ME, Gudbjartsson, D.F., T. Aspelund, Strachan, D.P., Launer, LJ (Lenore), Schadt, E. E., N. Chatterjee, Peter Almgren, Uitterlinden, André; id_orcid, J. Kaprio, Farrall, Martin, Surakka, I, Cooper, MN, Kahonen, Mika, Veronique Vitart, Rivadeneira, F., Neil R. Robertson, Viikari, J, Mooser, V, Rudan, Igor, I. Pichler, Lokki, M. L., Beckmann, Jacques S., Zitting, P., Michael C. Turchin, Inês Barroso, Wilson, J. F., Levinson, Douglas F, van Ommen, G.J.B, Heid, IM., Joyce B. J. van Meurs, Kraft, P. (Peter), Weedon, Michael N, P. Almgren, Sovio, U., Völzke, H., König, I.R., Estrada, Karol, Johnson, Toby, Heard-Costa, N.L. (Nancy), J. Shi, O'Donnell, Christopher J, Ke Hao, Andrew R. Wood, Meitinger, T, J. J. Hottenga, Manfred Kayser, P. Deloukas, T. Quertermous, Thorsteinsdottir, U., N. Pellikka, Eric E. Schadt, Boomsma, DI, O. Melander, Thomas Kocher, O. Raitakari +999 morecore +1 more sourceMachine Learning to Identify Critical Biomarker Profiles in New SARS-CoV-2 Variants
MicroorganismsThe global dissemination of SARS-CoV-2 resulted in the emergence of several variants, including Alpha, Alpha + E484K, Beta, and Omicron. Our research integrated the study of eukaryotic translation factors and fundamental components in general protein ...Christoph Schatz, Ludwig Knabl, Hye Kyung Lee, Rita Seeboeck, Dorothee von Laer, Eliott Lafon, Wegene Borena, Harald Mangge, Florian Prüller, Adelina Qerimi, Doris Wilflingseder, Wilfried Posch, Johannes Haybaeck +12 moredoaj +1 more sourceThe Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background
Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz +8 morewiley +1 more sourceHD-and-RNA-variants-Chr23.vcf
, 2017 All HD and RNAseq variants on chromosome 23.Thomas Lopdell (511314), Thomas Johnson (363281), Russell Snell (387740), Christine Couldrey (169434), Maksim Struchalin (166855), Ric Sherlock (511317), Mathew Littlejohn (4690033), Steve Davis (5017841), Kathryn Tiplady (511313), Richard Spelman (387738), Michael Keehan (4690036) +10 morecore +1 more sourceVenetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia
Pediatric Blood &Cancer, EarlyView.ABSTRACT
Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna +9 morewiley +1 more sourceHD-and-RNA-variants-Chr14.vcf
, 2017 All HD and RNAseq variants on chromosome 14.Thomas Lopdell (511314), Thomas Johnson (363281), Russell Snell (387740), Christine Couldrey (169434), Maksim Struchalin (166855), Ric Sherlock (511317), Mathew Littlejohn (4690033), Steve Davis (5017841), Kathryn Tiplady (511313), Richard Spelman (387738), Michael Keehan (4690036) +10 morecore +1 more source
