Results 111 to 120 of about 1,347,601 (289)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Solution of Fractional Delay Linear Integro-differential Equations Using Variational Approach and Approximate method

Journal of Kufa for Mathematics and Computer, 2013
In this paper fractional linear integro-differential equations with and without delays is studied, and solving such equations by using the variational approach and singularity methods.    
Fadhel Subhi Fadhel, Saad Naji Al-Azawi, Thekra Abdul Latiff Ibrahem   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Variational functionals for two-dimensional equilibrium and stability problems of Cosserat-Timoshenko elastic rods [PDF]

Инженерно-строительный журнал, 2013
This article deals with nonlinear two-dimensional problem of the theory of elastic Cosserat-Timoshenko rods in the material (Lagrangian) description with energy conjugate stress and deformation vectors.
V.V. Lalin, L.A. Rozin, D.A. Kushova
doaj  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Lagrangian structures and multidimensional consistency [PDF]

, 2010
The conventional point of view is that the Lagrangian is a scalar object (or equivalently a volume form), which through the Euler-Lagrange equations provides us with one single equation (i.e., one per component of the dependent variable ...
Lobb, Sarah Beverley
core   +2 more sources

Variational Methods for an Impulsive Fractional Differential Equations with Derivative Term

, 2019
This paper is devoted to studying the existence of solutions to a class of impulsive fractional differential equations with derivative dependence. The used technical approach is based on variational methods and iterative methods.
Haibo Chen, Jiafa Xu, Yulin Zhao
core   +1 more source

On indirect variational formulations for operator equations

, 2020
A scheme for the construction of indirect variational formulations for a wide class of equations is ...
Budotchkina S.A., Savchin V.M.
core   +1 more source