Results 121 to 130 of about 7,875,654 (350)

Variational Methods for an Impulsive Fractional Differential Equations with Derivative Term [PDF]

, 2019
This paper is devoted to studying the existence of solutions to a class of impulsive fractional differential equations with derivative dependence. The used technical approach is based on variational methods and iterative methods.
Haibo Chen, Jiafa Xu, Yulin Zhao
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Comparison between variational iteration method and Gegenbauer–Galerkin method for solving two dimensional nonlinear Volterra integral equations of the second kind [PDF]

AIP Advances
This paper intends to introduce two numerical techniques—the variational iteration method and the Gegenbauer–Galerkin method—for obtaining solutions to two dimensional nonlinear Volterra integral equations of the second kind.
M. H. Ahmed
doaj   +1 more source

Sensitivity analysis and parameter estimation for distributed hydrological modeling: potential of variational methods [PDF]

, 2009
Variational methods are widely used for the analysis and control of computationally intensive spatially distributed systems. In particular, the adjoint state method enables a very efficient calculation of the derivatives of an objective function ...
Dartus, Denis, Saulnier, G.-M., D. Dartus, F.-X. Le Dimet, Castaings, William, Le Dimet, François-Xavier, G.-M. Saulnier, W. Castaings, Saulnier, Georges-Marie   +8 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

On the convergence of adaptive nonconforming finite element methods for a class of convex variational problems [PDF]

, 2011
We formulate and analyze an adaptive nonconforming finite element method for the solution of convex variational problems. The class of minimization problems we admit includes highly singular problems for which no Euler–Lagrange equation (or inequality ...
Christoph Ortner, Ortner, Christoph, Praetorius, Dirk, Dirk Praetorius   +3 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Quasiperiodic Solutions of Completely Resonant Wave Equations with Quasiperiodic Forced Terms

Abstract and Applied Analysis, 2014
This paper is concerned with the existence of quasiperiodic solutions with two frequencies of completely resonant, quasiperiodically forced nonlinear wave equations subject to periodic spatial boundary conditions.
Yixian Gao, Weipeng Zhang, Jing Chang
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Variational Methods for Almost Periodic Solutions of a Class of Neutral Delay Equations

Abstract and Applied Analysis, 2008
We provide new variational settings to study the a.p. (almost periodic) solutions of a class of nonlinear neutral delay equations. We extend Shu and Xu (2006) variational setting for periodic solutions of nonlinear neutral delay equation to the ...
M. Ayachi, J. Blot
doaj   +1 more source