Results 71 to 80 of about 18,872 (309)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Necessary optimality conditions for fractional action-like problems with intrinsic and observer times [PDF]
, 2008 We prove higher-order Euler-Lagrange and DuBois-Reymond stationary conditions to fractional action-like variational problems.
Frederico, G.S.F., Torres, D.F.M.
core +1 more source
The Variational Origin of Motion by Gaussian Curvature [PDF]
, 2007 A variational formulation of an image analysis problem has the nice feature that it is often easier to predict the effect of minimizing a certain energy functional than to interpret the corresponding Euler-Lagrange equations.
Solem, Jan Erik +4 more
core +1 more source
A variational formulation for GTM through time [PDF]
2008 IEEE International Joint Conference on Neural Networks (IEEE World Congress on Computational Intelligence), 2008 Generative Topographic Mapping (GTM) is a latent variable model that, in its original version, was conceived to provide clustering and visualization of multivariate, realvalued, i.i.d. data. It was also extended to deal with noni-i.i.d. data such as multivariate time series in a variant called GTM Through Time (GTM-TT), defined as a constrained Hidden ...
Iván Olier, Alfredo Vellido
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Fourier-Cattaneo equation: stochastic origin, variational formulation, and asymptotic limits [PDF]
, 2022 We introduce a variational structure for the Fourier-Cattaneo (FC) system which is a second-order hyperbolic system. This variational structure is inspired by the large-deviation rate functional for the Kac process which is closely linked to the FC ...
Montefusco, Alberto (Dr.) +2 more
core
A Hamiltonian formulation of causal variational principles [PDF]
Calculus of Variations and Partial Differential Equations, 2017 32 pages, LaTeX, 1 figure, minor corrections (published version)
Finster, Felix, Kleiner, Johannes
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Acoustic displacement triangle based on the individual element test [PDF]
, 2012 A three node, displacement based, acoustic element is developed. In order to avoid spurious rotational modes, a higher order stiffness is introduced. The higher order stiffness is developed from an incompatible strain field which computes element volume ...
Correa, S. +2 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source