Results 61 to 70 of about 11,179,949 (250)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Some Problems on Variational Iteration Method [PDF]

, 2015
In this research project paper, I introduce some basic idea of Variational iteration method and its algorithm to solve the equations ODE & PDE, fractional differential equation, fractal differential equation and differential-difference equations.
Patra, Jaysmita
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Variational Approach of Marangoni Mixed Convection Boundary Layer Flow with Pade Technique

Journal of Applied Fluid Mechanics, 2016
In this paper, Variational Iteration method with combining Pade approximation (Modified Variational Iteration Method-MVIM) is performed to Marangoni convection flow over the surface with buoyancy effects which is occurred gravity and external pressure ...
Murat Gubes, Galip Oturanc
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Optimal Homotopy Asymptotic Method for the Solution of Higher-Order Boundary Value Problems in Finite Domains

Abstract and Applied Analysis, 2012
We solve some higher-order boundary value problems by the optimal homotopy asymptotic method (OHAM). The proposed method is capable to handle a wide variety of linear and nonlinear problems effectively.
Javed Ali, S. Islam, Hamid Khan, Syed Inayat Ali Shah   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Applying he's variational iteration method for solving differential- difference equation [PDF]

, 2008
We extend He's variational iteration method (VIM) to find the approximate solutions for nonlinear differential-difference equation. Simple but typical examples are applied to illustrate the validity and great potential of the generalized variational ...
Yildirim, Ahmet, Yildirim A.
core   +1 more source

Numerical Solution of the Uncertain Characteristic Cauchy Reaction-Diffusion Equation by Variational Iteration Method

Walailak Journal of Science and Technology, 2013
In this paper, the uncertain characteristic Cauchy reaction-diffusion equation is solved by the variational iteration method. The uncertain characteristic Cauchy problem is converted to a system of characteristic Cauchy problems by parametric ...
Hamid ROUHPARVAR, Saeid ABBASBANDY
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source