Results 91 to 100 of about 30,988,225 (367)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Numerical Solution of the Inverse Problem of Determining an Unknown Source Term in a Heat Equation

Journal of Applied Mathematics, 2012
This paper investigates the inverse problem of determining a heat source in the parabolic heat equation using the usual conditions. Firstly, the problem is reduced to an equivalent problem which is easy to handle using variational iteration method ...
Xiuming Li, Suping Qian
doaj   +1 more source

Variational method and duality in the 2D square Potts model

, 1997
The ferromagnetic q-state Potts model on a square lattice is analyzed, for q>4, through an elaborate version of the operatorial variational method. In the variational approach proposed in the paper, the duality relations are exactly satisfied, involving ...
Baxter R J, Baxter R J, Bhattacharya T, Bhattacharya T, Binder K, Briggs K M, Buffenoir E, Burley D M, Huang K, I Sardella, Janke W, Kelland S B, Klümper A, L Angelini, M Pellicoro, M Villani, Mittag L, Morita T, Munster A, Pearce P A, Tsang S K   +20 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

The Variate Difference Method

Southern Economic Journal, 1940
Commission's seal on t.-p. ; Bibliographical foot-notes. ; Mode of access: Internet.
Edgar Z. Palmer, Gerhard Tintner
openaire   +2 more sources

Combining $2D$ synchrosqueezed wave packet transform with optimization for crystal image analysis

, 2015
We develop a variational optimization method for crystal analysis in atomic resolution images, which uses information from a 2D synchrosqueezed transform (SST) as input.
Lu, Jianfeng, Wirth, Benedikt, Yang, Haizhao   +2 more
core   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Constructions of new abundant traveling wave solutions for system of the ion sound and Langmuir waves by the variational direct method

Results in Physics, 2021
In this paper, a novel and simple approach called the variational direct method (VDM) is applied to construct the exact traveling wave solutions of the system of ion sound and Langmuir waves (SEISLWs), which is under the influence of the ponderomotive ...
Kang-Jia Wang, Hong-Wei Zhu, Xiao-Lian Liu, Guo-Dong Wang   +3 more
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source