Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Mean photon number dependent variational method to the Rabi model
New Journal of Physics, 2015 We present a mean photon number dependent variational method, which works well in the whole coupling regime if the photon energy is dominant over the spin-flipping, to evaluate the properties of the Rabi model for both the ground state and excited states.
Maoxin Liu +3 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Physics-Constrained Data-Driven Variational Method for Discrepancy Modeling. [PDF]
Comput Methods Appl Mech Eng, 2023 Masud A, Nashar S, Goraya S.
europepmc +1 more source
The beryllium atom, ions, and iso-electronic ions in magnetic field using the variational Monte Carlo method [PDF]
, 2023 S. B. Doma, G.D. Roston, M. F. Ahmed
openalex +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Application of the Variational Method to the Large Deformation Problem of Thin Cylindrical Shells with Different Moduli in Tension and Compression. [PDF]
Materials (Basel), 2023 He XT, Wang XG, Sun JY.
europepmc +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Analytical Model for Early Design Stage of Cable-Stayed Suspension Bridges Based on Hellinger-Reissner Variational Method. [PDF]
Materials (Basel), 2022 Feng Q +5 more
europepmc +1 more source