Results 81 to 90 of about 31,512,198 (344)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Variational iteration method with matrix Lagrange multiplier for nonlinear oscillators

Journal of Low Frequency Noise, Vibration and Active Control, 2019
The variational iteration method is a famous mathematical tool to nonlinear oscillator, this paper shows that the method can be further improved by using matrix Lagrange multipliers.
Zhao-Ling Tao, Guo-Hua Chen, Yi-Han Chen
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Matrix product state on a quantum computer

New Journal of Physics
Solving quantum many-body systems is one of the most significant regimes where quantum computing applies. Currently, as a hardware-friendly computational paradigms, variational algorithms are often used for finding the ground energy of quantum many-body ...
Yong Liu, Guangyao Huang, Yizhi Wang, Junjie Wu   +3 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Ritz Variational Method for the Flexural Analysis of Rectangular Kirchhoff Plate on Winkler Foundation

Журнал інженерних наук, 2019
In this study, the Ritz variational method has been applied to solve the bending problem of rectangular Kirchhoff plate resting on Winkler foundation for the case of simply supported edges and transverse distributed load.
Ike C. C.
doaj   +1 more source

Adaptive Variational Mode Decomposition Method for Eliminating Instrument Noise in Turbulence Detection [PDF]

, 2020
Yang He, Zheng Sheng, Yanwei Zhu, Mingyuan He   +3 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Physics-Constrained Data-Driven Variational Method for Discrepancy Modeling. [PDF]

Comput Methods Appl Mech Eng, 2023
Masud A, Nashar S, Goraya S.
europepmc   +1 more source