Results 81 to 90 of about 328,225 (327)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modified Viscosity Subgradient Extragradient-Like Algorithms for Solving Monotone Variational Inequalities Problems

Axioms, 2020
Variational inequality theory is an effective tool for engineering, economics, transport and mathematical optimization. Some of the approaches used to resolve variational inequalities usually involve iterative techniques.
Nopparat Wairojjana, Mudasir Younis, Habib ur Rehman, Nuttapol Pakkaranang, Nattawut Pholasa   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A Statistically Principled and Computationally Efficient Approach to Speech Enhancement using Variational Autoencoders

, 2019
Recent studies have explored the use of deep generative models of speech spectra based of variational autoencoders (VAEs), combined with unsupervised noise models, to perform speech enhancement.
Deleforge, Antoine, Pariente, Manuel, Vincent, Emmanuel   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Matrix product state on a quantum computer

New Journal of Physics
Solving quantum many-body systems is one of the most significant regimes where quantum computing applies. Currently, as a hardware-friendly computational paradigms, variational algorithms are often used for finding the ground energy of quantum many-body ...
Yong Liu, Guangyao Huang, Yizhi Wang, Junjie Wu   +3 more
doaj   +1 more source

Variational iteration method with matrix Lagrange multiplier for nonlinear oscillators

Journal of Low Frequency Noise, Vibration and Active Control, 2019
The variational iteration method is a famous mathematical tool to nonlinear oscillator, this paper shows that the method can be further improved by using matrix Lagrange multipliers.
Zhao-Ling Tao, Guo-Hua Chen, Yi-Han Chen
doaj   +1 more source

Ritz Variational Method for the Flexural Analysis of Rectangular Kirchhoff Plate on Winkler Foundation

Журнал інженерних наук, 2019
In this study, the Ritz variational method has been applied to solve the bending problem of rectangular Kirchhoff plate resting on Winkler foundation for the case of simply supported edges and transverse distributed load.
Ike C. C.
doaj   +1 more source

A Stein variational Newton method

, 2018
Stein variational gradient descent (SVGD) was recently proposed as a general purpose nonparametric variational inference algorithm [Liu & Wang, NIPS 2016]: it minimizes the Kullback-Leibler divergence between the target distribution and its approximation
Cui, Tiangang, Detommaso, Gianluca, Marzouk, Youssef, Scheichl, Robert, Spantini, Alessio   +4 more
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source