Results 141 to 150 of about 292,354 (329)
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
THE STUDY OF IMPERFECT COMPLEXES. PART I. CALORIMETRIC STUDY OF COMPLEXES BY JOB'S METHOD OF CONTINUED VARIATION [PDF]
, 1948 SUSHIL KUMAR SIDDHANTA
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Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
A discontinuous problem involving the p-Laplacian operator and critical exponent in $mathbb{R}^N$
Electronic Journal of Differential Equations, 2003 Using convex analysis, we establish the existence of at least two nonnegative solutions for the quasilinear problem $$ -Delta_{p}u=H(u-a)u^{p^*-1} +lambda h(x)quadhbox{in }mathbb{R}^N $$ where $Delta_{p}u$ is the $p$-Laplacian operator, $H$ is the ...
Claudianor Oliveira Alves +1 more
doaj
Molecular Oncology, EarlyView.Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban +12 more
wiley +1 more source
Existence of solutions to nonlocal elliptic equations with discontinuous terms
Electronic Journal of Differential Equations, 2012 In this article, we study the existence of nonnegative solutions for the elliptic partial differential equation $$displaylines{ -[M(|u|^{p}_{1,p})]^{1,p}Delta_{p}u = f(x,u) quadhbox{in } Omega , cr u = 0 quadhbox{on } partialOmega , }$$ where ...
Francisco Julio S. A. Correa +1 more
doaj
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Closure to “Discussion of ‘A Short Method for the Evaluation of the Effect of Some Thermal-Cycle Variations on Steam-Turbine Heat Rates’” (1954, Trans. ASME, 76, pp. 663–664) [PDF]
, 1954 S. D. Fulton
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