Results 51 to 60 of about 57,276 (313)

Variations on Van Kampen’s Method [PDF]

open access: yesJournal of Mathematical Sciences, 2005
12 ...
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Variationally-based hybrid boundary element methods

open access: yesComputer Assisted Methods in Engineering and Science, 2023
The hybrid stress boundary element method (HSBEM) was introduced in 1987 on the basis of the Hellinger-Reissner potential, as a generalization of Pian's hybrid finite element method.
Ney Augusto Dumont
doaj  

Geometric Discretization of Lagrangian Mechanics and Field Theories [PDF]

open access: yes, 2009
This thesis presents a unified framework for geometric discretization of highly oscillatory mechanics and classical field theories, based on Lagrangian variational principles and discrete differential forms. For highly oscillatory problems in mechanics,
Stern, Ari Joshua
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Geometry of variational methods: dynamics of closed quantum systems

open access: yesSciPost Physics, 2020
We present a systematic geometric framework to study closed quantum systems based on suitably chosen variational families. For the purpose of (A) real time evolution, (B) excitation spectra, (C) spectral functions and (D) imaginary time evolution, we ...
Lucas Hackl, Tommaso Guaita, Tao Shi, Jutho Haegeman, Eugene Demler, J. Ignacio Cirac
doaj   +1 more source

Fractional variational problems depending on indefinite integrals

open access: yes, 2012
We obtain necessary optimality conditions for variational problems with a Lagrangian depending on a Caputo fractional derivative, a fractional and an indefinite integral.
Pooseh, Shakoor   +8 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Self-Adaptive Implicit Methods for Monotone Variant Variational Inequalities

open access: yesJournal of Inequalities and Applications, 2009
The efficiency of the implicit method proposed by He (1999) depends on the parameter heavily; while it varies for individual problem, that is, different problem has different "suitable" parameter, which is difficult to find.
Ge Zhili, Han Deren
doaj   +2 more sources

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