Results 61 to 70 of about 57,276 (313)
Control variational methods for differential equations [PDF]
, 2000 We review recent results established in the literature via the optimal control approach to differential equations, and we show that a systematic study of general variational inequalities associated to fourth-order operators can be performed by similar ...
Sprekels, Jürgen +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2020 We establish the existence of positive solutions for the singular quasilinear Schrödinger equation \begin{equation*} \begin{cases} -\Delta u -\Delta (u^{2})u=h(x) u^{-\gamma} + f(x,u)& \mbox{in } \Omega,\\ u(x)=0&\mbox{on }\partial \Omega, \end{cases ...
Ricardo Alves, Mariana Reis
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Variational Bayesian multinomial probit regression with Gaussian process priors [PDF]
, 2006 It is well known in the statistics literature that augmenting binary and polychotomous response models with Gaussian latent variables enables exact Bayesian analysis via Gibbs sampling from the parameter posterior.
Rogers, S., Girolami, M.
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
A variational method for $Φ^4_3$
, 2018 We introduce an explicit description of the $Φ^4_3$ measure on a bounded domain. Our starting point is the interpretation of its Laplace transform as the value function of a stochastic optimal control problem along the flow of a scale regularization parameter.
Barashkov, N., Gubinelli, M.
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
On analysis error covariances in variational data assimilation
, 2008 The problem of variational data assimilation for a nonlinear evolution model is formulated as an optimal control problem to find the initial condition function (analysis).
Shutyaev, V. +5 more
core +1 more source
Reissner's Mixed Variational Theorem toward MITC finite elements for multilayered plates [PDF]
, 2013 In this paper, we analyze a two dimensional model of multilayered plates for which the main interest is to study the mechanical and physical properties, that may change in the thickness direction.
Maria Cinefra +15 more
core +1 more source