Results 61 to 70 of about 292,354 (329)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

A Variational Perspective on Accelerated Methods in Optimization

, 2016
Accelerated gradient methods play a central role in optimization, achieving optimal rates in many settings. While many generalizations and extensions of Nesterov's original acceleration method have been proposed, it is not yet clear what is the natural ...
Jordan, Michael I., Wibisono, Andre, Wilson, Ashia C.   +2 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Implicit particle methods and their connection with variational data assimilation

, 2012
The implicit particle filter is a sequential Monte Carlo method for data assimilation that guides the particles to the high-probability regions via a sequence of steps that includes minimizations.
Alexandre J. Chorin, Arulampalam, Bennet, Bickel, Buehner, Cappé, Carpenter, Chorin, Chorin, Chorin, Chorin, Chorin, Conn, Cornebise, Courtier, Courtier, Dimet, Doucet, Doucet, Ethan Atkins, Evensen, Evensen, Evensen, Fedorenko, Fertig, Fletcher, Fournier, Geweke, Goodman, Gordon, Hammersley, Hunt, Johansen, Kalman, Kalman, Kalnay, Kalnay, Kalos, Kass, Kass, Kloeden, Kurapov, Liu, Liu, Liu, Liu, Lorenz, Matthias Morzfeld, Miller, Moral, Morzfeld, Morzfeld, Nocedal, Pitt, Rabier, Smith, Smídl, Snyder, Talagrand, Talagrand, Tremolet, van Leeuwen, van Leeuwen, Zupanski   +63 more
core   +3 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Self-Adaptive Implicit Methods for Monotone Variant Variational Inequalities

Journal of Inequalities and Applications, 2009
The efficiency of the implicit method proposed by He (1999) depends on the parameter heavily; while it varies for individual problem, that is, different problem has different "suitable" parameter, which is difficult to find.
Ge Zhili, Han Deren
doaj   +2 more sources

Polynomial mechanics and optimal control

, 2015
We describe a new algorithm for trajectory optimization of mechanical systems. Our method combines pseudo-spectral methods for function approximation with variational discretization schemes that exactly preserve conserved mechanical quantities such as ...
Srinivasan, Akshay, Venkadesan, Madhusudhan   +1 more
core   +1 more source

Variational Methods for Normal Integration [PDF]

Journal of Mathematical Imaging and Vision, 2017
The need for an efficient method of integration of a dense normal field is inspired by several computer vision tasks, such as shape-from-shading, photometric stereo, deflectometry, etc. Inspired by edge-preserving methods from image processing, we study in this paper several variational approaches for normal integration, with a focus on non-rectangular
Jean-François Aujol, Jean-François Aujol, Yvain Quéau, Jean-Denis Durou   +3 more
openaire   +5 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

About existence and regularity of positive solutions for a quasilinear Schrödinger equation with singular nonlinearity

Electronic Journal of Qualitative Theory of Differential Equations, 2020
We establish the existence of positive solutions for the singular quasilinear Schrödinger equation \begin{equation*} \begin{cases} -\Delta u -\Delta (u^{2})u=h(x) u^{-\gamma} + f(x,u)& \mbox{in } \Omega,\\ u(x)=0&\mbox{on }\partial \Omega, \end{cases ...
Ricardo Alves, Mariana Reis
doaj   +1 more source