Results 71 to 80 of about 292,354 (329)

Discrete Variational Optimal Control

, 2012
This paper develops numerical methods for optimal control of mechanical systems in the Lagrangian setting. It extends the theory of discrete mechanics to enable the solutions of optimal control problems through the discretization of variational ...
A. Iserles, A. Weinstein, A.I. Bobenko, A.M. Bloch, A.M. Bloch, D. Iglesias, David Martín de Diego, E. Hairer, E. Martínez, F. Bullo, F. Jiménez, Fernando Jiménez, I. Hussein, J. Cortés, J.C. Marrero, J.E. Marsden, J.E. Marsden, J.E. Marsden, J.E. Marsden, J.E. Marsden, M. Kobilarov, M. Kobilarov, M. Kobilarov, Marin Kobilarov, N. Bou-Rabee, R. Abraham, S. Ferraro, S. Ober-Blöbaum, T. Lee   +28 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Perturbation and Variational Methods in Nonextensive Tsallis Statistics

, 1998
A unified presentation of the perturbation and variational methods for the generalized statistical mechanics based on Tsallis entropy is given here. In the case of the variational method, the Bogoliubov inequality is generalized in a very natural way ...
A. K. Rajagopal, A. M. Salzberg, A. Plastino, A. R. Plastino, B. H. Lavenda, B. H. Lavenda, B. H. Lavenda, B. H. Lavenda, B. J. Hiley, B. M. Boghosian, C. Tsallis, C. Tsallis, C. Tsallis, C. Tsallis, D. F. Torres, D. H. Zanette, E. K. Lenzi, E. M. F. Curado, E. M. F. Curado, E. M. F. Curado, I. Koponen, J. Binney, J. J. Aly, J. Klafter, J. O. Indekeu, J. O. Indekeu, J. P. Bouchaud, L. C. Malacarne, L. P. Chimento, L. Tisza, M. F. Shlesinger, M. F. Shlesinger, M. O. Caceres, P. Jund, P. T. Landsberg, R. P. Feynman, R. S. Mendes, R. S. Mendes, S. A. Cannas, S. K. Ma, V. H. Hamity   +40 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Infinitely many solutions for a Hénon-type system in hyperbolic space

Advances in Difference Equations, 2020
This paper is devoted to studying the semilinear elliptic system of Hénon type {−ΔBNu=K(d(x))Qu(u,v),−ΔBNv=K(d(x))Qv(u,v),u,v∈Hr1(BN),N≥3, $$ \textstyle\begin{cases} -\Delta _{\mathbb{B}^{N}}u= K(d(x))Q_{u}(u,v), \\ -\Delta _{\mathbb{B}^{N}}v= K(d(x))Q_ ...
Patrícia Leal da Cunha, Flávio Almeida Lemos   +1 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Variational Inference in Nonconjugate Models

, 2013
Mean-field variational methods are widely used for approximate posterior inference in many probabilistic models. In a typical application, mean-field methods approximately compute the posterior with a coordinate-ascent optimization algorithm.
Blei, David M., Wang, Chong
core  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source