Results 111 to 120 of about 5,497,042 (305)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Tomato breeding for open ground in the south of Russia

Овощи России
Relevance. Tomato is the most widespread vegetable crop in the southern regions of Russia and one of the most popular with the population in all natural and climatic zones of the country.
M. R. Engalychev, E. A. Dzhos, A. A. Matyukina, O. V. Verba, E. V. Demidenko, V. S. Sosnov, A. А. Rubtsov   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

3Was of Static Software Testing Techniques

, 2011
No fault detection technique is capable of finding all classes of fault in software, so we have to use variety of techniques that will help us to ensure that a variety of faults are found, resulting in more effective testing.
Dr. SHEIKH UMAR FAROOQ S. M. K. QUADRI
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The prospects of winter rye breeding on productivity and grain quality in the steppe Zavolzhie

Зерновое хозяйство России, 2018
Winter soft wheat is a promising crop for growing in the Middle Urals. At present its cultivation is constantly increasing in the agricultural farms of the Sverdlov region. The amount of sowing areas ranges from 1.5 to 3 thousand hectares.
E. N. Shabolkina, A. A. Bisharev, L. V. Pronovich   +2 more
doaj   +2 more sources

Testing a Variety of Encryption Technologies [PDF]

, 2001
Review and test speeds of various encryption technologies using Entrust Software. Multiple encryption algorithms are included in the product. Algorithms tested were IDEA, CAST, DES, and RC2. Test consisted of taking a 7.7 MB Word document file which included complex graphics and timing encryption, decryption and signing.
openaire   +2 more sources

Advances in Alfalfa Variety Development and Testing [PDF]

, 1994
Alfalfa (Medicago sativa) is historically the highest yielding, highest quality forage legume grown in Kentucky. It forms the basis of Kentucky\u27s cash hay enterprise and is an important component in dairy, horse, beef and sheep diets.
Vincelli, Paul C., Henning, Jimmy C., Lauriault, Leonard M., Parr, John C., Brown, Linda G., Lacefield, Garry D.   +5 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source