Results 71 to 80 of about 18,105,956 (255)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Grain quality of different type of rice varieties under different environments and cultivation techniques

Journal of Agriculture and Food Research
Enhancing quality has become a pivotal goal in rice production. However, the effects of temperature and light environments on rice quality across different varieties were unclear.
Kun Liu, Danping Hou, Chenyu Wang, Hong Zhao, Li Ren, Shan Deng, Yu Zhang, Jingli Zhang, Jian Huang, Yiying Zhang, Shouguo Li, Jingyan Huang, Hairong Chen, Yunxia Chu, Lijun Liu   +14 more
doaj   +1 more source

Technical Equipment of Corn Breeding and Seed Production

Сельскохозяйственные машины и технологии, 2020
The development of the subprogram “Maize Breeding and Seed Production Development” within the framework of the Federal Scientific and Technical Program for the Development of Agriculture for 2017–2025 determines the necessity for intensive technical ...
S. A. Davydova, M. E. Chaplygin
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

AGROBIOLOGICAL ASSESSMENT OF SOME ROMANIAN SEA BUCKTHORN GENOTYPES [PDF]

Fruit Growing Research, 2018
Recently the sea buckthorn is come a cultivated species. The research on this species should be focused on more efficient harvesting method, new cultivars suitable to European climate; bigger yields by right cultivation methods, pest and diseases control.
Ancu Irina, Stanciu Cosmina Luminita, Sturzeanu Monica, Sestras Adriana   +3 more
doaj  

Stages of national varietal plant recourses forming in the State Legislative Regulation system of Ukraine during 1923-2013

Plant Varieties Studying and Protection, 2013
The article deals with analysis of scientific publications in the field of plant breeding, seed production and variety testing, archival documents and published government regulations.
П. М. Василюк
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source