Results 11 to 20 of about 18,583 (222)

Prediction of steps in the evolution of variola virus host range. [PDF]

PLoS ONE, 2014
Variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. Although smallpox has been eradicated by a World Health Organization vaccination program, knowledge of the evolutionary processes
Chad Smithson, Alex Purdy, Adrian J Verster, Chris Upton   +3 more
doaj   +2 more sources

EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses [PDF]

Journal of Immunology Research, 2015
Concerns that variola viruses might be used as bioweapons have renewed the interest in developing new and safer smallpox vaccines. Variola virus genomes are now widely available, allowing computational characterization of the entire T-cell epitome and ...
Magdalena Molero-Abraham, John-Paul Glutting, Darren R. Flower, Esther M. Lafuente, Pedro A. Reche   +4 more
doaj   +3 more sources

Between the Real and the Imagined: Variola Vera Epidemic in the Area of Yugoslavia Through Film Narrative [PDF]

Etnoantropološki Problemi, 2019
The ideas about the epidemics of infectious diseases, both imagined and those that are known to human societies, are becoming more frequent topic of popular culture, that is the film industry.
Marina Mandić
doaj   +2 more sources

Research with variola virus after smallpox eradication: Development of a mouse model for variola virus infection.

PLoS Pathogens, 2021
In this issue of PLOS Pathogens, Hutson and coworkers at the Centers for Disease Control and Prevention (CDC) in Atlanta, USA describe a study with infectious variola virus that was approved by the World Health Organization (WHO) Advisory Committee on ...
Bernard Moss, Geoffrey L Smith
doaj   +2 more sources

Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age [PDF]

, 2020
Smallpox, one of the most devastating human diseases, killed between 300 million and 500 million people in the 20th century alone. We recovered viral sequences from 13 northern European individuals, including 11 dated to ~600-1050 CE, overlapping the ...
Moiseyev, Vyacheslav, Smith, GL, Strand, LM, Sikora, Martin, Strand, Lisa Mariann, Holtsmark Nielsen, Sofie, Castro, Constanza De La Fuente, Fouchier, Ron A. M., Allentoft, ME, Jones, Terry C., Muhlemann, B, Smith, Derek, Pushkina, Tamara, Sikora, M, Nielsen, SH, Vinner, Lasse, Drosten, C, Hansen, Anders Johannes, Buzhilova, Alexandra, Østergaard Sørensen, Palle, Moiseyev, V, Smith, Geoffrey L., Magnusson, Y, Fouchier, Ron; id_orcid, Vinner, L, Hansen, Anders J., Magnusson, Yvonne, Sutter, Gerd, Margaryan, A, Smith, Derek J, Fouchier, Ron A M, Falys, Ceri, Fouchier, Ron A.M., Gustin, I, Wilhelmson, H, Khartanovich, V, Jones, Terry C, Buzhilova, A, Schroeder, Hannes, Schroeder, H, Jorkov, MLS, Bill, Jan, Pushkina, T, Willerslev, E, Hansen, AJ, Falys, C, Smith, Geoffrey L, Jones, TC, Nielsen, Sofie Holtsmark, Drosten, Christian, Allentoft, Morten E, Damgaard, PD, Bill, J, de la Fuente Castro, Constanza, Sørensen, Palle Østergaard, Sutter, G, Willerslev, Eske, Castro, CD, de Barros Damgaard, Peter, Khartanovich, Valeri, Sorensen, PO, Mühlemann, Barbara, Fouchier, Ron, Wilhelmson, Helene, Gustin, Ingrid, Smith, Derek J., Margaryan, Ashot, Allentoft, Morten E., Damgaard, Peter De Barros, Jørkov, Marie Louise Schjellerup   +69 more
core   +3 more sources

Development of CMX001 for the Treatment of Poxvirus Infections

Viruses, 2010
CMX001 (phosphonic acid, [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]mono[3-(hexadecyloxy)propyl] ester) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir (CDV).
George Painter, Merrick Almond, Rose O’Mahony, Wendy Painter, Michelle Rose, Scott Foster, Alice Robertson, Bernhard Lampert, Tim Tippin, Lawrence Trost, Randall Lanier   +10 more
doaj   +1 more source

VARIOLA. [PDF]

JAMA: The Journal of the American Medical Association, 1901
n ...
openaire   +2 more sources

Poxvirus Viability and Signatures in Historical Relics

Emerging Infectious Diseases, 2014
Although it has been >30 years since the eradication of smallpox, the unearthing of well-preserved tissue material in which the virus may reside has called into question the viability of variola virus decades or centuries after its original occurrence ...
Andrea M. McCollum, Yu Li, Kimberly Wilkins, Kevin L. Karem, Whitni B. Davidson, Christopher D. Paddock, Mary G. Reynolds, Inger K. Damon   +7 more
doaj   +1 more source

Should Remaining Stockpiles of Smallpox Virus (Variola) Be Destroyed?

Emerging Infectious Diseases, 2011
In 2011, the World Health Organization will recommend the fate of existing smallpox stockpiles, but circumstances have changed since the complete destruction of these cultures was first proposed.
Raymond S. Weinstein
doaj   +1 more source

Development of a High-Content Orthopoxvirus Infectivity and Neutralization Assays. [PDF]

PLoS ONE, 2015
Currently, a number of assays measure Orthopoxvirus neutralization with serum from individuals, vaccinated against smallpox. In addition to the traditional plaque reduction neutralization test (PRNT), newer higher throughput assays are based on ...
Irina Gates, Victoria Olson, Scott Smith, Nishi Patel, Inger Damon, Kevin Karem   +5 more
doaj   +1 more source