Results 61 to 70 of about 881,071 (281)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Reasoned opinion on the modification of the existing MRLs for difenoconazole in peppers and aubergines [PDF]

open access: yesEFSA Journal, 2014
In accordance with Article 6 of Regulation (EC) No 396/2005, Greece, hereafter referred to as the evaluating Member State (EMS), received an application from SYGENTA HELLAS ABEE to modify the existing MRLs for the active substance difenoconazole in ...
European Food Safety Authority
doaj   +1 more source

Reproduction of Pratylenchus penetrans on various rotation crops in Quebec [PDF]

open access: yes, 2002
La reproduction du nématode des lésions racinaires Pratylenchus penetrans a été évaluée en serre sur 12 cultures de rotation. La moutarde brune (Brassica juncea) a été la meilleure plante hôte et a augmenté de 17,2 fois la population initiale.
Bélair, G.   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Reasoned opinion on the modification of the existing MRLs for spirotetramat in olives for oil production [PDF]

open access: yesEFSA Journal, 2014
In accordance with Article 6 of Regulation (EC) No 396/2005, Austria, hereafter referred to as the evaluating Member State (EMS), received an application from Bayer CropScience to modify the existing Maximum Residue Level (MRL) for the active substance ...
European Food Safety Authority
doaj   +1 more source

Food Court [PDF]

open access: yes, 2013
This article, focusing on produce and grain, discusses the environmental and climate change impacts of food production, processing, packaging, and distribution, which ultimately contribute to both economic and social costs.
Czarnezki, Jason J.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Modification of the existing maximum residue levels for fosetyl‐Al in tree nuts, pome fruit, peach and potato

open access: yesEFSA Journal, 2018
In accordance with Article 6 of Regulation (EC) No 396/2005, the applicants Bayer CropScience Europe and Oxon Italia S.p.A. submitted requests to the competent national authority in Spain and Italy, respectively, to modify the existing maximum residue ...
European Food Safety Authority (EFSA)   +25 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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