Results 81 to 90 of about 7,601,054 (231)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
PRICE, YIELD, AND GROSS REVENUE VARIABILITY FOR SELECTED GEORGIA CROPS [PDF]
Demand and Price Analysis,
Lin, Kuang-Hsing T. +1 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2015 This is a most encouraging book, 8 inches square and presenting eight fables bilingually. As the bilingual editor's note indicates, we have eight young illustrators, each quite particular, chosen by competition.
Various
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Reasoned opinion on the modification of the existing MRLs for fluopyram in various crops
EFSA Journal, 2014 In accordance with Article 6 of Regulation (EC) No 396/2005, Germany, hereafter referred to as the evaluating Member State (EMS), received an application from Bayer CropScience AG to modify the existing MRLs for the active substance fluopyram in various ...
European Food Safety Authority
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Reasoned opinion on the modification of the existing MRLs for abamectin in various crops
EFSA Journal, 2015 In accordance with Article 6 of Regulation (EC) No 396/2005, the Netherlands, hereafter referred to as the evaluating Member State (EMS), received an application from Syngenta Crop Protection AG to modify the existing maximum residue levels (MRLs) for ...
European Food Safety Authority
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Price Incentives, Nonprice factors, and Crop Supply Response:The Indian Cash Crops [PDF]
Agriculture as a source of growth was sorely neglected in the early development strategies of the currently developing countries. Realisation of this shortcoming prompted public policy in these countries to encourage agriculture by various means.
SUNIL KANWAR
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