Results 51 to 60 of about 443,542 (283)

P38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level [PDF]

, 1997
The cytokine tumor necrosis factor (TNF) alpha was found to stimulate the p38 mitogen activated protein (MAP) kinase signalling cascade in human umbilical vein endothelial cells.
Gaestel, M. (Matthias), Jong, N. (Netty) de, Koster, J.F. (Johan), Lee, J.C. (John), Pietersma, A. (Anna), Sluiter, W.J. (Wim), Tilly, B.C. (Bernard)   +6 more
core   +3 more sources

Vascular adhesion protein‐1 blockade suppresses choroidal neovascularization

The FASEB Journal, 2008
ABSTRACT Vascular adhesion protein‐1 (VAP‐1) is an endothelial cell adhesion molecule involved in leukocyte recruitment. Leukocytes and, in particular, macrophages play an important role in the development of choroidal neovascularization (CNV), an integral component of age‐related macular degeneration (AMD ...
Kousuke, Noda, Haicheng, She, Toru, Nakazawa, Toshio, Hisatomi, Shintaro, Nakao, Lama, Almulki, Souska, Zandi, Shinsuke, Miyahara, Yasuhiro, Ito, Kennard L, Thomas, Rebecca C, Garland, Joan W, Miller, Evangelos S, Gragoudas, Yukihiko, Mashima, Ali, Hafezi-Moghadam   +14 more
openaire   +3 more sources

Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy

Journal of Ophthalmology, 2015
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR.
Jianbo He, Hong Wang, Ying Liu, Wen Li, Dorothy Kim, Hu Huang   +5 more
doaj   +1 more source

Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction

Scientific Reports, 2021
Stroke is a multiphasic process involving a direct ischemic brain injury which is then exacerbated by the influx of immune cells into the brain tissue. Activation of brain endothelial cells leads to the expression of adhesion molecules such vascular cell
Lori N. Eidson, Qingzeng Gao, Hongyan Qu, Daniel S. Kikuchi, Ana Carolina P. Campos, Elizabeth A. Faidley, Yu-Yo Sun, Chia-Yi Kuan, Rosana L. Pagano, Bernard Lassègue, Malú G. Tansey, Kathy K. Griendling, Marina S. Hernandes   +12 more
doaj   +1 more source

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

Insulin-Regulated Increase of Soluble Vascular Adhesion Protein-1 in Diabetes [PDF]

The American Journal of Pathology, 2002
Vascular adhesion protein-1 (VAP-1) is one of the molecules on the endothelial cell membrane, which may guide inflammatory cells into atherosclerotic lesions. This dual function molecule may also contribute to the pathogenesis of atherosclerosis and other vasculopathies via its enzymatic activity that oxidizes primary amines to produce their ...
Marko, Salmi, Craig, Stolen, Pekka, Jousilahti, Gennady G, Yegutkin, Päivi, Tapanainen, Tuula, Janatuinen, Mikael, Knip, Sirpa, Jalkanen, Veikko, Salomaa   +8 more
openaire   +2 more sources

Localization of vascular adhesion protein-1 (VAP-1) in the human eye [PDF]

Experimental Eye Research, 2010
Recently we showed a critical role for Vascular Adhesion Protein-1 (VAP-1) in rodents during acute ocular inflammation, angiogenesis, and diabetic retinal leukostasis. However, the expression of VAP-1 in the human eye is unknown. VAP-1 localization was therefore investigated by immunohistochemistry.
Lama, Almulki, Kousuke, Noda, Shintaro, Nakao, Toshio, Hisatomi, Kennard L, Thomas, Ali, Hafezi-Moghadam   +5 more
openaire   +2 more sources

Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3

Food & Nutrition Research, 2019
Background: Inflammation in endothelial cells induces production of inflammatory cytokines and monocytes adhesion, which are crucial events in the initiation of atherosclerosis.
Tomomi Iwashima, Yuki Kudome, Yoshimi Kishimoto, Emi Saita, Miori Tanaka, Chie Taguchi, Satoshi Hirakawa, Nobu Mitani, Kazuo Kondo, Kaoruko Iida   +9 more
doaj   +1 more source

Anti-Inflammatory and Anti-Thrombogenic Properties of Arterial Elastic Laminae

Bioengineering, 2023
Elastic laminae, an elastin-based, layered extracellular matrix structure in the media of arteries, can inhibit leukocyte adhesion and vascular smooth muscle cell proliferation and migration, exhibiting anti-inflammatory and anti-thrombogenic properties.
Jeremy Goldman, Shu Q. Liu, Brandon J. Tefft   +2 more
doaj   +1 more source

Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction [PDF]

, 2015
Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase
Cantatore, S, De Carlo, D, Fineschi, Vittorio, Fiore, C, Neri, M, Riezzo, I, Turillazzi, E   +6 more
core   +1 more source