Results 1 to 10 of about 2,366,029 (213)
25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes
Journal of Lipid Research, 2021 The oxysterol sulfate, 25-hydroxycholesterol 3-sulfate (25HC3S), has been shown to play an important role in lipid metabolism, inflammatory response, and cell survival. However, the mechanism(s) of its function in global regulation is unknown.
Yaping Wang +6 more
doaj +1 more source
Frontiers in Endocrinology, 2022 AimTo determine the effect of safranal on diabetic retinopathy in vitro and its possible mechanisms.MethodsWe used human retinal microvascular endothelial cells (HRMECs) to test the influence of safranal in vitro.
Qin Xiao +19 more
doaj +1 more source
Redox Report, 2022 Objectives Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Oxidative stress resulting from high glucose promotes accumulation of ECM and development of DN. Activation of Nrf2 could attenuate oxidative
Huankai Yao +5 more
doaj +1 more source
Effect of High Glucose on Vasculature [PDF]
Circulation, 2003 To the Editor: Cosentino et al1 report that high glucose causes PKC-dependent upregulation of inducible cyclooxygenase and endothelial NO synthase (eNOS) expression in human aortic endothelial cells associated with a selective increase of thromboxane production and reduced NO release.
MARFELLA, Raffaele +2 more
openaire +3 more sources
Open Medicine, 2022 As a common complication of diabetes, diabetic pain neuropathy (DPN) is caused by neuron intrinsic and extrinsic factors. Neuron intrinsic factors include neuronal apoptosis and oxidative stress, while extrinsic factors are associated with glial ...
Yang Guang, Shi Jinxin
doaj +1 more source
Effects of High Glucose and Lipotoxicity on Diabetic Podocytes [PDF]
Nutrients, 2021 Glomerular podocytes are highly differentiated cells that cover glomerular capillaries from the outside and have a characteristic morphology with numerous foot processes. The formation of slit membranes between the foot processes serves as a final filtration barrier for urine filtration from the blood.
Nakamichi, Ran +2 more
openaire +2 more sources
High Glucose Causes Distinct Expression Patterns of Primary Human Skin Cells by RNA Sequencing
Frontiers in Endocrinology, 2021 Diabetes-related skin problems represent the most common long-term complications in diabetes mellitus patients. These complications, which include diabetic dermopathy, diabetic blisters, necrobiosis lipoidica diabeticorum, and eruptive xanthomatosis, may
Shan Zhang +7 more
doaj +1 more source
Impact of High Altitudes on Glucose Control [PDF]
Journal of Diabetes Science and Technology, 2011 Airplane flight results in exposure to hypobaric conditions. At cruising altitude, usually 10,000 to 13,000 meters (∼30,000 to 42,000 feet), the pressure in the cabin is 0.75 atm, which is 75% of the pressure measured at sea level. The difference in pressure between 1.0 and 0.75 atm is what passengers experience as temporary ear discomfort at take-off ...
Johan, Jendle, Peter, Adolfsson
openaire +2 more sources
High Glucose Shifts the Oxylipin Profiles in the Astrocytes towards Pro-Inflammatory States
Metabolites, 2021 Hyperglycemia is associated with several complications in the brain, which are also characterized by inflammatory conditions. Astrocytes are responsible for glucose metabolism in the brain and are also important participants of inflammatory responses ...
Dmitry V. Chistyakov +3 more
doaj +1 more source
Frontiers in Genetics, 2021 Background: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. MicroRNAs (miRNAs), members of non-coding RNAs, have been frequently reported to regulate various diseases including DR.
Haijun Zhao, Yanhui He
doaj +1 more source