Results 11 to 20 of about 2,366,029 (213)
Transient High-Glucose Exposure and Erk Signaling [PDF]
Circulation ReportsTransient high-glucose exposure induces Erk2 phosphorylation and cell proliferation in human coronary artery endothelial cells (HCAEC), but the upstream mechanisms remain unclear.HCAEC were exposed to 183 mg/dL L-glucose or D-glucose for 1 h followed by 23 h in a glucose-free medium.
Okada, Junichi +3 more
openaire +3 more sources
Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses [PDF]
, 2015 Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while ...
Hara, Manami +2 more
core +14 more sources
Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1/Nrf2 pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Renal tubular damage is critical pathological feathers of diabetic nephropathy (DN). This study aimed to explore the protective activity and related mechanisms of crocin in renal epithelial cell injury induced by high glucose.Materials and ...
Jichen Zhang +5 more
doaj +1 more source
High glucose induces autophagy in podocytes [PDF]
Experimental Cell Research, 2013 Autophagy is a cellular pathway involved in protein and organelle degradation. It is relevant to many types of cellular homeostasis and human diseases. High level of glucose is known to inflict podocyte injury, but little is reported about the relationship between high concentrations of glucose and autophagy in these cells.
Tean, Ma +5 more
openaire +2 more sources
Diseases, 2021 Chronic hyperglycemia-induced thioredoxin-interacting protein (TXNIP) expression, associated oxidative/nitrosative stress (ROS/RNS), and mitochondrial dysfunction play critical roles in the etiology of diabetic retinopathy (DR).
Lalit Pukhrambam Singh +1 more
doaj +1 more source
Effect of high glucose condition on glucose metabolism in primary astrocytes
Brain Research, 2020 In the brain, glucose enters astrocytes through glucose transporter (GLUT1) and either enters glycolysis or the glycogen shunt. Astrocytes meet the energy needs of neurons by building up and breaking down their glycogen supply. High glucose exposure causes astrocyte dysregulation, but its effects on glucose metabolism are relatively unknown.
Kelly Staricha +6 more
openaire +3 more sources
Cells, 2020 Diabetic retinopathy is a prevalent microvascular complication characterized by apoptotic vascular cell loss in the retina. Previous studies have shown that high glucose (HG)-induced mitochondrial fragmentation plays a critical role in promoting retinal ...
Dongjoon Kim +2 more
doaj +1 more source
Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient
Pharmaceuticals, 2021 Hyperglycemic environment-induced oxidative stress-mediated matrix metalloproteinase-1 (MMP-1) plays a crucial role in the degradation of the extracellular matrix (ECM), which might contribute to premature skin aging.
Yun-Zhen Wu +3 more
doaj +1 more source
Glucose Metabolism in Pregnancy at High Altitude [PDF]
Diabetes Care, 2001 OBJECTIVE—To assess insulin sensitivity and β-cell function associated with lower maternal fasting plasma glucose levels at high altitude compared with sea level. RESEARCH DESIGN AND METHODS—We studied 215 pregnant women at 8–42 weeks of gestation in Peru.
Krampl, E +4 more
openaire +3 more sources
Frontiers in Nutrition, 2023 Diabetic retinopathy (DR) is a major cause of vision loss in diabetic patients. Hyperglycemia-induced oxidative stress and the accumulation of inflammatory factors result in blood-retinal barrier dysfunction and the pathogenesis of DR. Scoparia dulcis L.
Heng-Dao Lin +20 more
doaj +1 more source