Results 1 to 10 of about 121,217 (160)
Human umbilical vein endothelial cell miRNA secretome highlights endothelial origin of serum miRNAs [PDF]
Scientific ReportsMicroRNAs are key contributors to blood-based biomarker research, however their potential is hindered by the “noise” of their abundance even in healthy blood.
Nora J. Doleschall +6 more
doaj +2 more sources
The functional properties of a truncated form of endothelial cell protein C receptor generated by alternative splicing [PDF]
Haematologica, 2008 Background A soluble form of endothelial cell protein C receptor (sEPCR) is generated by shedding of the cellular form. sEPCR binds to protein C and factor VIIa and inhibits both the activation of protein C and the activity of activated protein C and ...
Eva Molina +4 more
doaj +2 more sources
Uric Acid Promotes Human Umbilical Vein Endothelial Cell Senescence In Vitro [PDF]
MetabolitesBackground/Objectives: Uric acid can act as a prooxidant or an antioxidant; therefore, its effects on human umbilical vein endothelial cells (HUVECs) were investigated to better understand its role in promoting cellular senescence and vascular ...
Katarzyna Lewandowska +4 more
doaj +2 more sources
Molecular Therapy: Nucleic Acids, 2021 Atherosclerosis is the main cause of cardio-cerebrovascular diseases. Endothelial-mesenchymal transition plays an important role in atherosclerosis. Icariin has a protective effect on atherosclerosis; however, the underlying mechanism remains unclear. In
Shan Liu +6 more
doaj +1 more source
SAGE Open Medicine, 2021 Objectives: This study reports the levels of cytokines, chemokines, and growth factors previously identified as taking part in the pathology of atherosclerosis in human umbilical vein endothelial cells derived from mothers with type 2 diabetes and ...
Samar Sultan
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background The small GTPase RhoA (Ras homolog gene family, member A) regulates a variety of cellular processes, including cell motility, proliferation, survival, and permeability.
Michael Hauke +5 more
doaj +1 more source
Adaptive induction of growth differentiation factor 15 attenuates endothelial cell apoptosis in response to high glucose stimulus. [PDF]
PLoS ONE, 2013 Growth differentiation factor 15 (GDF15), a direct target gene of p53, is a multifunctional member of the TGF-β/BMP superfamily. GDF15 can be induced and is implicated as a key secretory cytokine in response to multiple cellular stimuli.
Jun Li +5 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2023 Objective LncRNA PART1 has been confirmed related to multiple cancer bioactivities mediated with vascular endothelial growth factor signaling. Nevertheless, the role of LncRNA PART1 in esophageal cancer induced angiogenesis remains unclear.
Naixin Ding MM +6 more
doaj +1 more source
Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Severe hindlimb ischemia is a chronic disease with poor prognosis that can lead to amputation or even death. This study aimed to assess the therapeutic effect of liraglutide on hind‐limb ischemia in type 2 diabetic mice and to elucidate the ...
Yu‐xin Zhu +11 more
doaj +1 more source
Compensatory Feto-Placental Upregulation of the Nitric Oxide System during Fetal Growth Restriction [PDF]
, 2012 Background: Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally ...
Begliuomini, Silvia +11 more
core +10 more sources