Results 61 to 70 of about 444,049 (319)

変形性膝関節炎患者膝関節液中の細胞外マトリックス成分と可溶性VCAM-1 [PDF]

, 1997
It is generally accepted that the number of patients with osteoarthritis (OA) of the knee must increase in the future because of the increase of the aged. The pathogenic mechanisms of OA haven't been elucidated yet, but it is supposed that mediate pannus
Endo, Hiroshi, Ichimura, Mitsuko, Nakata, Yasunari, Okamoto, Motoi, Sakiyama, Junko, Tohge, Hiroko   +5 more
core   +1 more source

Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3

Food & Nutrition Research, 2019
Background: Inflammation in endothelial cells induces production of inflammatory cytokines and monocytes adhesion, which are crucial events in the initiation of atherosclerosis.
Tomomi Iwashima, Yuki Kudome, Yoshimi Kishimoto, Emi Saita, Miori Tanaka, Chie Taguchi, Satoshi Hirakawa, Nobu Mitani, Kazuo Kondo, Kaoruko Iida   +9 more
doaj   +1 more source

Anti-Inflammatory and Anti-Thrombogenic Properties of Arterial Elastic Laminae

Bioengineering, 2023
Elastic laminae, an elastin-based, layered extracellular matrix structure in the media of arteries, can inhibit leukocyte adhesion and vascular smooth muscle cell proliferation and migration, exhibiting anti-inflammatory and anti-thrombogenic properties.
Jeremy Goldman, Shu Q. Liu, Brandon J. Tefft   +2 more
doaj   +1 more source

Immunolocalization of Vascular Adhesion Protein-1 in Human Conjunctival Tumors

Ophthalmic Research, 2012
<i>Objective:</i> We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans. <i>Methods:</i> Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were ...
Junichi, Fukuhara, Satoru, Kase, Kousuke, Noda, Miyuki, Murata, Mika, Noda, Ryo, Ando, Zhenyu, Dong, Atsuhiro, Kanda, Susumu, Ishida   +8 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

12(S)‐hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose‐induced vascular injury

Journal of Diabetes Investigation, 2019
Aims/Introduction Diabetes is an important risk factor for atherosclerotic disease. The initiating factor of atherosclerosis is local endothelial cell injury.
Xiaofang Wang, Lu Gao, Lili Xiao, Lulu Yang, Wenshu Li, Gangqiong Liu, Linlin Chen, Jinying Zhang   +7 more
doaj   +1 more source

Chlorella 11-Peptide Inhibits the Production of Macrophage-Induced Adhesion Molecules and Reduces Endothelin-1 Expression and Endothelial Permeability

Marine Drugs, 2013
The inflammation process in large vessels involves the up-regulation of vascular adhesion molecules such as endothelial cell selectin (E-selectin), intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) which are ...
Jong Yuh Cherng, Mei Fen Shih, Lih Chi Chen   +2 more
doaj   +1 more source

Adhesion of endothelial cells and adsorption of serum proteins on gas plasma-treated polytetrafluoroethylene [PDF]

, 1991
From in vitro experiments it is known that human endothelial cells show poor adhesion to hydrophobic polymers. The hydrophobicity of vascular prostheses manufactured from Teflon® or Dacron® may be the reason why endothelialization of these grafts does ...
Aken, W.G. van, Bantjes, A., Beugeling, T., Dekker, A., Feijen, J., Reitsma, K.   +5 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science
Disturbed blood flow and the resulting oscillatory low shear stress (OSS) are key contributors to vascular endothelial dysfunction and the initiation of atherosclerosis.
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
doaj   +1 more source