Results 71 to 80 of about 444,049 (319)

Vascular adhesion protein‐1 blockade suppresses choroidal neovascularization

The FASEB Journal, 2008
ABSTRACT Vascular adhesion protein‐1 (VAP‐1) is an endothelial cell adhesion molecule involved in leukocyte recruitment. Leukocytes and, in particular, macrophages play an important role in the development of choroidal neovascularization (CNV), an integral component of age‐related macular degeneration (AMD ...
Kousuke, Noda, Haicheng, She, Toru, Nakazawa, Toshio, Hisatomi, Shintaro, Nakao, Lama, Almulki, Souska, Zandi, Shinsuke, Miyahara, Yasuhiro, Ito, Kennard L, Thomas, Rebecca C, Garland, Joan W, Miller, Evangelos S, Gragoudas, Yukihiko, Mashima, Ali, Hafezi-Moghadam   +14 more
openaire   +3 more sources

Insulin-Regulated Increase of Soluble Vascular Adhesion Protein-1 in Diabetes [PDF]

The American Journal of Pathology, 2002
Vascular adhesion protein-1 (VAP-1) is one of the molecules on the endothelial cell membrane, which may guide inflammatory cells into atherosclerotic lesions. This dual function molecule may also contribute to the pathogenesis of atherosclerosis and other vasculopathies via its enzymatic activity that oxidizes primary amines to produce their ...
Marko, Salmi, Craig, Stolen, Pekka, Jousilahti, Gennady G, Yegutkin, Päivi, Tapanainen, Tuula, Janatuinen, Mikael, Knip, Sirpa, Jalkanen, Veikko, Salomaa   +8 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Tumor-Endothelium Cross Talk Blocks Recruitment of Neutrophils to Endothelial Cells: A Novel Mechanism of Endothelial Cell Anergy

Neoplasia: An International Journal for Oncology Research, 2009
Tumor cells have evolved effective strategies to escape the host immune response. The objective of this study was to determine whether tumor cells can condition endothelial cells in a specific manner to prevent subsequent adhesion of polymorphonuclear ...
Roman A. Blaheta, Maciej Powerski, Lukasz Hudak, Eva Juengel, Dietger Jonas, Andreas von Knethen, Hans Willhelm Doerr, Jindrich Cinatl, Jr   +7 more
doaj   +1 more source

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +2 more
core   +1 more source

Safety of Blocking Vascular Adhesion Protein‐1 in Patients with Contact Dermatitis [PDF]

Basic & Clinical Pharmacology & Toxicology, 2005
Abstract: Vascular adhesion protein‐1 mediates leukocyte binding to vascular endothelia and migration to tissues. It is upregulated in inflammatory conditions. We studied the safety of vascular adhesion protein‐1 blockade by a single dose of the mouse monoclonal antibody vepalimomab in patients with nickel‐induced allergic contact dermatitis lesions ...
Petri J, Vainio, Outi, Kortekangas-Savolainen, Jari H, Mikkola, Kimmo, Jaakkola, Kirsti, Kalimo, Sirpa, Jalkanen, Timo, Veromaa   +6 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hispidulin Inhibits the Vascular Inflammation Triggered by Porphyromonas gingivalis Lipopolysaccharide

Molecules, 2023
Hispidulin is a natural bioactive flavonoid that has been studied for its potential therapeutic properties, including its anti-inflammatory, antioxidant, and neuroprotective effects.
Yeon Kim, Hoyong Lee, Hyun-Joo Park, Mi-Kyoung Kim, Yong-Il Kim, Hyung Joon Kim, Soo-Kyung Bae, Yung-Jin Kim, Moon-Kyoung Bae   +8 more
doaj   +1 more source

Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]

, 2009
Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena, Bukin, Eugenij, Friedl, Peter, Gröger, Marion, Hofer-Warbinek, Renate, Ignatyev, George, Knapp, Sylvia, Matt, Ulrich, Pasteiner, Waltraud, Petzelbauer, Peter, Reingruber, Sonja, Zacharowski, Kai, Zinkl, Daniela   +12 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source