Vessels in Middle-Earth: meeting report from the 2025 Australasian Summit on Vascular Biology and Microcirculation [PDF]
Vascular BiologyThe 2025 Australasian Summit on Vascular Biology and Microcirculation, jointly hosted by the Australian Vascular Biology Society (AVBS) and the Australian and New Zealand Microcirculation Society (ANZMS), convened in Queenstown, New Zealand, bringing ...
Kazuhide S Okuda +3 more
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The multifaceted roles of PI3Kγ in hypertension, vascular biology, and inflammation [PDF]
, 2016 PI3Kγ is a multifaceted protein, crucially involved in cardiovascular and immune systems. Several studies described the biological and physiological functions of this enzyme in the regulation of cardiovascular system, while others stressed its role in ...
Carnevale, Daniela +2 more
core +5 more sources
Bone-derived PDGF-BB drives brain vascular calcification in male mice
The Journal of Clinical Investigation, 2023 Brain vascular calcification is a prevalent age-related condition often accompanying neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel calcifications in peripheral tissue is well studied, but microvascular calcification ...
Jiekang Wang +8 more
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Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
JCI Insight, 2023 Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle cells (SMCs).
Marycarmen Arévalo Martínez +14 more
doaj +1 more source
Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice
JCI Insight, 2021 Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by ...
Haixia Zhang +15 more
doaj +1 more source
Nuclear receptors in vascular biology [PDF]
, 2015 Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla +56 more
core +3 more sources
Radiotherapy exposure directly damages the uterus and causes pregnancy loss
JCI Insight, 2023 Female cancer survivors are significantly more likely to experience infertility than the general population. It is well established that chemotherapy and radiotherapy can damage the ovary and compromise fertility, yet the ability of cancer treatments to ...
Meaghan J. Griffiths +17 more
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BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis [PDF]
, 2004 Plant steroid hormones, brassinosteroids (BRs), are perceived by the plasma membrane-localized leucine-rich-repeat-receptor kinase BRI1. Based on sequence similarity, we have identified three members of the BRI1 family, named BRL1, BRL2 and BRL3.
Caño Delgado, Ana +8 more
core +1 more source
Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth
JCI Insight, 2022 The placenta is the primary organ for immune regulation, nutrient delivery, gas exchange, protection against environmental toxins, and physiologic perturbations during pregnancy.
Abhineet M. Sharma +9 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Vascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin family, a class III histone deacetylase and a key epigenetic ...
Wenxin Li +10 more
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