Results 21 to 30 of about 447,238 (255)
JCI Insight, 2021 The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that progerin induces repetitive nuclear membrane (NM)
Paul H. Kim +9 more
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The Journal of Clinical Investigation, 2022 Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk in myeloproliferative disorders and in clonal hematopoiesis.
Wenli Liu +13 more
doaj +1 more source
Nuclear Receptors in Vascular Biology [PDF]
Current Atherosclerosis Reports, 2015 Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics. In response to these diverse but critically important mediators, nuclear receptors regulate the homeostatic control of lipids, carbohydrate ...
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HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes
JCI Insight, 2021 Patients with diabetes with coronary microvascular disease (CMD) exhibit higher cardiac mortality than patients without CMD. However, the molecular mechanism by which diabetes promotes CMD is poorly understood.
Rui Si +14 more
doaj +1 more source
JCI Insight, 2023 Based upon our demonstration that the smooth muscle cell–selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6’s role in SMCs in vivo using cell type–specific knockout ...
Meng Zou +9 more
doaj +1 more source
Vascular biology of the biliary epithelium [PDF]
Journal of Gastroenterology and Hepatology, 2013 AbstractgraphicCholangiocytes are involved in a variety of processes essential for liver pathophysiology. To meet their demanding metabolic and functional needs, bile ducts are nourished by their own arterial supply, the peribiliary plexus. This capillary network originates from the hepatic artery and is strictly arranged around the intrahepatic bile ...
Morell CM, FABRIS, LUCA, Strazzabosco M.
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ROS-producing immature neutrophils in giant cell arteritis are linked to vascular pathologies
JCI Insight, 2020 Giant cell arteritis (GCA) is a common form of primary systemic vasculitis in adults, with no reliable indicators of prognosis or treatment responses.
Lihui Wang +12 more
doaj +1 more source
Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth
JCI Insight, 2022 The placenta is the primary organ for immune regulation, nutrient delivery, gas exchange, protection against environmental toxins, and physiologic perturbations during pregnancy.
Abhineet M. Sharma +9 more
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The Journal of Clinical Investigation, 2022 Vascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin family, a class III histone deacetylase and a key epigenetic ...
Wenxin Li +10 more
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The Future of Vascular Biology and Medicine [PDF]
Circulation, 2016 During the past several decades, landmark discoveries in the field of vascular biology have evolved our understanding of the biology of blood vessels and the pathobiology of local and systemic vascular disease states and have led to novel disease-modifying therapies for patients.
Scott, Kinlay +2 more
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